LOCUS       SIU01966.1               238 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            URACIL PHOSPHORIBOSYLTRANSFERASE UPP (UMP PYROPHOSPHORYLASE)
            (UPRTASE) (UMP DIPHOSPHORYLASE) protein.
ACCESSION   LT708304-3380
PROTEIN_ID  SIU01966.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="upp"
                     /locus_tag="BQ2027_MB3337C"
                     /note="Mb3337c, upp, len: 207 aa. Equivalent to Rv3309c,
                     len: 207 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 207 aa overlap). Probable upp, uracil
                     phosphoribosyltransferase (EC 2.4.2.9), identical to
                     P94928|UPP uracil phosphoribosyltransferase from
                     Mycobacterium bovis (207 aa). Also similar to others e.g.
                     P36399|UPP_STRSL from Streptococcus salivarius (209 aa),
                     FASTA scores: opt: 658, E(): 4.7e-35, (48.3% identity in
                     207 aa overlap); Q9A194|UPP|SPY0392 from Streptococcus
                     pyogenes (209 aa), FASTA scores: opt:650, E(): 1.5e-34,
                     (47.35% identity in 207 aa overlap); Q9RE01|UPP from
                     Lactobacillus plantarum (209 aa), FASTA scores: opt: 644,
                     E(): 3.7e-34, (46.4% identity in 207 aa overlap); etc.
                     BELONGS TO THE UPRTASE FAMILY. Protein product from
                     Mb3337c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb3337c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A659"
                     /db_xref="InterPro:IPR000836"
                     /db_xref="InterPro:IPR005765"
                     /db_xref="InterPro:IPR029057"
                     /db_xref="InterPro:IPR034332"
                     /db_xref="UniProtKB/Swiss-Prot:P0A659"
BEGIN
        1 MDGVDRSRGW THPYQPPFRG PSHDCYIGFN AVQVHVVDHP LAAARLTTLR DERTDNAGFR
       61 AALRELTLLL IYEATRDAPC EPVPIRTPLA ETVGSRLTKP PLLVPVLRAG LGMVDEAHAA
      121 LPEAHVGFVG VARDEQTHQP VPYLDSLPDD LTDVPVMVLD PMVATGGSMT HTLGLLISRG
      181 AADITVLCVV AAPEGIAALQ KAAPNVRLFT AAIDEGLNEV AYIVPGLGDA GDRQFGPR
//