LOCUS SIU01966.1 238 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE URACIL PHOSPHORIBOSYLTRANSFERASE UPP (UMP PYROPHOSPHORYLASE) (UPRTASE) (UMP DIPHOSPHORYLASE) protein. ACCESSION LT708304-3380 PROTEIN_ID SIU01966.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="upp" /locus_tag="BQ2027_MB3337C" /note="Mb3337c, upp, len: 207 aa. Equivalent to Rv3309c, len: 207 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 207 aa overlap). Probable upp, uracil phosphoribosyltransferase (EC 2.4.2.9), identical to P94928|UPP uracil phosphoribosyltransferase from Mycobacterium bovis (207 aa). Also similar to others e.g. P36399|UPP_STRSL from Streptococcus salivarius (209 aa), FASTA scores: opt: 658, E(): 4.7e-35, (48.3% identity in 207 aa overlap); Q9A194|UPP|SPY0392 from Streptococcus pyogenes (209 aa), FASTA scores: opt:650, E(): 1.5e-34, (47.35% identity in 207 aa overlap); Q9RE01|UPP from Lactobacillus plantarum (209 aa), FASTA scores: opt: 644, E(): 3.7e-34, (46.4% identity in 207 aa overlap); etc. BELONGS TO THE UPRTASE FAMILY. Protein product from Mb3337c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3337c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P0A659" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="UniProtKB/Swiss-Prot:P0A659" BEGIN 1 MDGVDRSRGW THPYQPPFRG PSHDCYIGFN AVQVHVVDHP LAAARLTTLR DERTDNAGFR 61 AALRELTLLL IYEATRDAPC EPVPIRTPLA ETVGSRLTKP PLLVPVLRAG LGMVDEAHAA 121 LPEAHVGFVG VARDEQTHQP VPYLDSLPDD LTDVPVMVLD PMVATGGSMT HTLGLLISRG 181 AADITVLCVV AAPEGIAALQ KAAPNVRLFT AAIDEGLNEV AYIVPGLGDA GDRQFGPR //