LOCUS       SIU01965.1               534 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PHOSPHOMANNOMUTASE PMMB (PHOSPHOMANNOSE MUTASE) protein.
ACCESSION   LT708304-3379
PROTEIN_ID  SIU01965.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pmmB"
                     /locus_tag="BQ2027_MB3336"
                     /note="Mb3336, pmmB, len: 534 aa. Equivalent to Rv3308,
                     len: 534 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 534 aa overlap). Probable pmmB,
                     phosphomannomutase (EC 5.4.2.8), equivalent to
                     Q9CCL7|PMMB|ML0706 PUTATIVE PHOSPHO-SUGAR MUTASE from
                     Mycobacterium leprae (538 aa), FASTA scores: opt: 2681,
                     E(): 1.4e-150, (76.95% identity in 538 aa overlap). Also
                     similar to others e.g. Q9AD82|SCK13.08c from Streptomyces
                     coelicolor (549 aa), FASTA scores: opt: 1378, E():
                     8.9e-74, (46.7% identity in 529 aa overlap); Q9ZHL4|PMM
                     (FRAGMENT so no homology at N-terminus for this one) from
                     Haemophilus ducreyi (443 aa), FASTA scores: opt: 935, E():
                     9.6e-48, (39.4% identity in 449 aa overlap);
                     P18159|YHXB_BACSU from Bacillus subtilis (565 aa), FASTA
                     scores: opt: 776, E(): 2.7e-38, (31.7% identity in 574 aa
                     overlap); etc. Contains PS00710 Phosphoglucomutase and
                     phosphomannomutase phosphoserine signature. BELONGS TO THE
                     PHOSPHOHEXOSE MUTASES FAMILY. Protein product from Mb3336
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3336 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y5J3"
                     /db_xref="InterPro:IPR005841"
                     /db_xref="InterPro:IPR005843"
                     /db_xref="InterPro:IPR005844"
                     /db_xref="InterPro:IPR005845"
                     /db_xref="InterPro:IPR005846"
                     /db_xref="InterPro:IPR016055"
                     /db_xref="InterPro:IPR016066"
                     /db_xref="InterPro:IPR036900"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5J3"
BEGIN
        1 MTPENWIAHD PDPQTAAELA ACGPDELKAR FSRPLAFGTA GLRGHLRGGP DAMNLAVVLR
       61 ATWAVARVLT DRGLAGSPVI VGRDARHGSP AFAAAAAEVL AAAGFSVLLL PDPAPTPVVA
      121 FAVRHTGAAA GIQITASHNP ATDNGYKVYV DGGLQLLAPT DRQIEAAMAT APPADQIARK
      181 TVNPSENRAS DLIDRYIQRA AGVRRCAGSV RVALTPLHGV GGAMAVETLR RAGFTEVHTV
      241 ATQFAPNPDF PTVTLPNPEE PGATDALLTL ATDVDADVAI ALDPDADRCA VGIPTVSGWR
      301 MLSGDETGWL LGDYILSQTD DRASPPETRV VASTVVSSRM LAAIAAHHAA VHVETLTGFK
      361 WLARADANLP GTLVYAYEEA IGHCVDPTAV RDKDGISAAV LVCDLVAALK GQGRSVTDAL
      421 DELARCYGVH EVAALSRPVG GAVETTDLMR RLREDPPRRL AGFPATVTDI GDTLILTGGD
      481 DNMLVRVAVR PSGTEPKLKC YLEIRCAVTG DLPAARQLVR ARIDELSASV RRWW
//