LOCUS SIU01965.1 534 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE PHOSPHOMANNOMUTASE PMMB (PHOSPHOMANNOSE MUTASE) protein. ACCESSION LT708304-3379 PROTEIN_ID SIU01965.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="pmmB" /locus_tag="BQ2027_MB3336" /note="Mb3336, pmmB, len: 534 aa. Equivalent to Rv3308, len: 534 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 534 aa overlap). Probable pmmB, phosphomannomutase (EC 5.4.2.8), equivalent to Q9CCL7|PMMB|ML0706 PUTATIVE PHOSPHO-SUGAR MUTASE from Mycobacterium leprae (538 aa), FASTA scores: opt: 2681, E(): 1.4e-150, (76.95% identity in 538 aa overlap). Also similar to others e.g. Q9AD82|SCK13.08c from Streptomyces coelicolor (549 aa), FASTA scores: opt: 1378, E(): 8.9e-74, (46.7% identity in 529 aa overlap); Q9ZHL4|PMM (FRAGMENT so no homology at N-terminus for this one) from Haemophilus ducreyi (443 aa), FASTA scores: opt: 935, E(): 9.6e-48, (39.4% identity in 449 aa overlap); P18159|YHXB_BACSU from Bacillus subtilis (565 aa), FASTA scores: opt: 776, E(): 2.7e-38, (31.7% identity in 574 aa overlap); etc. Contains PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. Protein product from Mb3336 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3336 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y5J3" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="UniProtKB/TrEMBL:A0A1R3Y5J3" BEGIN 1 MTPENWIAHD PDPQTAAELA ACGPDELKAR FSRPLAFGTA GLRGHLRGGP DAMNLAVVLR 61 ATWAVARVLT DRGLAGSPVI VGRDARHGSP AFAAAAAEVL AAAGFSVLLL PDPAPTPVVA 121 FAVRHTGAAA GIQITASHNP ATDNGYKVYV DGGLQLLAPT DRQIEAAMAT APPADQIARK 181 TVNPSENRAS DLIDRYIQRA AGVRRCAGSV RVALTPLHGV GGAMAVETLR RAGFTEVHTV 241 ATQFAPNPDF PTVTLPNPEE PGATDALLTL ATDVDADVAI ALDPDADRCA VGIPTVSGWR 301 MLSGDETGWL LGDYILSQTD DRASPPETRV VASTVVSSRM LAAIAAHHAA VHVETLTGFK 361 WLARADANLP GTLVYAYEEA IGHCVDPTAV RDKDGISAAV LVCDLVAALK GQGRSVTDAL 421 DELARCYGVH EVAALSRPVG GAVETTDLMR RLREDPPRRL AGFPATVTDI GDTLILTGGD 481 DNMLVRVAVR PSGTEPKLKC YLEIRCAVTG DLPAARQLVR ARIDELSASV RRWW //