LOCUS       SIU01957.1               305 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Pseudouridine
            synthase (EC , PA2043 type protein.
ACCESSION   LT708304-3371
PROTEIN_ID  SIU01957.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3328C"
                     /EC_number="4.2.1.70"
                     /note="Mb3328c, -, len: 305 aa. Equivalent to Rv3300c,
                     len: 305 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 305 aa overlap). Conserved hypothetical
                     protein, similar to various proteins (notably pseudoridine
                     synthase family proteins) e.g. Q9RJ76|SCI41.08 PUTATIVE
                     RIBOSOMAL PSEUDOURIDINE SYNTHASE from Streptomyces
                     coelicolor (324 aa), FASTA scores: opt: 876, E(): 4.5e-48,
                     (52.1% identity in 313 aa overlap); Q9I272|PA2043
                     HYPOTHETICAL PROTEIN from Pseudomonas aeruginosa (300 aa),
                     FASTA scores: opt: 676, E(): 1.8e-35, (42.55% identity in
                     268 aa overlap); Q9JZW8|NMB0867 YABO/YCEC/SFHB FAMILY
                     PROTEIN from Neisseria meningitidis (serogroup B) (307
                     aa), FASTA scores: opt: 597, E(): 1.8e-30, (42.9% identity
                     in 282 aa overlap); Q9JUY2|NMA1085 HYPOTHETICAL PROTEIN
                     from Neisseria meningitidis (serogroup A) (307 aa), FASTA
                     scores: opt: 597, E(): 1.8e-30, (42.9% identity in 282 aa
                     overlap); Q12362|RIB2_YEAST|RIB2|YOL066C DRAP DEAMINASE
                     (PSEUDOURIDINE SYNTHASE FAMILY PROTEIN) from Saccharomyces
                     cerevisiae (Baker's yeast) (591 aa), FASTA scores: opt:
                     338, E(): 6.9e-14, (32.95% identity in 246 aa overlap);
                     Q9RTS2|DR1684 PUTATIVE PSEUDOURIDINE SYNTHASE from
                     Deinococcus radiodurans (321 aa), FASTA scores: opt: 319,
                     E(): 6.5e-13, (32.75% identity in 235 aa overlap); etc.
                     Also similar to Mycobacterium tuberculosis hypothetical
                     protein Q10786|Y04P_MYCTU|MTCY48.25c|Rv1540|MT1592 (308
                     aa) (28.8% identity in 299 aa overlap). Mb3328c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3U6"
                     /db_xref="InterPro:IPR006145"
                     /db_xref="InterPro:IPR006224"
                     /db_xref="InterPro:IPR020103"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3U6"
BEGIN
        1 MALRPEDRLL SVHDVLGPVR VRLLGGSVLA ELTARFGVAA RAKVLAGEVV DNDGAVVDSG
       61 TVLPPGSVVH LYRDLPDEVP VPFDVPVLHQ DADIVVVDKP HFLATMPRGR HVAQTALVRL
      121 RRELGLPELS PAHRLDRLTA GVLLFTTRRE VRGSYQTMFA RGLVRKTYLA RAPVAPGLAL
      181 PRLVRSRIVK RRGHLQAVCE PGVPNAETLV ERIARDGLYR LTPTTGRTHQ LRVHMAALGI
      241 PIMGDPLYPN VISVAAHDFS TPLQLLAQRI EFDDPLTGSH REFASTRTLT GATLPTWSAA
      301 ADCRP
//