LOCUS       SIU01956.1               970 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ARYLSULFATASE ATSB (ARYL-SULFATE SULPHOHYDROLASE) (SULFATASE)
            protein.
ACCESSION   LT708304-3370
PROTEIN_ID  SIU01956.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="atsB"
                     /locus_tag="BQ2027_MB3327C"
                     /note="Mb3327c, atsB, len: 970 aa. Equivalent to Rv3299c,
                     len: 970 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.9% identity in 970 aa overlap). Probable atsB,
                     arylsulfatase (EC 3.1.6.1), similar to
                     P51691|ARS_PSEAE|ATSA|PA0183 (alias CAA88421|ATSA) from
                     Pseudomonas aeruginosa (535 aa), FASTA scores: opt: 645,
                     E(): 5.8e-31, (32.0% identity in 550 aa overlap);
                     Q9L4Y2|ATSA from Klebsiella pneumoniae (577 aa), FASTA
                     scores: opt: 504, E(): 1.7e-22, (26.3% identity in 566 aa
                     overlap); and P20713|ATSA|ARS_KLEAE (precursor) from
                     Klebsiella pneumoniae (464 aa), FASTA scores: opt: 502,
                     E(): 1.8e-22, (26.85% identity in 451 aa overlap). Also
                     similar to Mycobacterium tuberculosis proteins
                     O06776|MTI376.13c|ATSD|Rv0663 (787 aa) (43.6% identity in
                     796 aa overlap) and P95059|MTCY210.30|ATSA|R0711 (787 aa)
                     (38.4% identity in 797 aa overlap). Equivalent to AAK47741
                     from Mycobacterium tuberculosis strain CDC1551 (992 aa)
                     but shorter 22 aa. Contains PS00523 Sulfatases signature 1
                     and PS01095 Chitinases family 18 active site signature.
                     BELONGS TO THE SULFATASE FAMILY. Protein product from
                     Mb3327c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb3327c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y4G2"
                     /db_xref="InterPro:IPR000917"
                     /db_xref="InterPro:IPR009200"
                     /db_xref="InterPro:IPR017850"
                     /db_xref="InterPro:IPR024607"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4G2"
BEGIN
        1 MMSEDNALVL VAGYQDLDSA RHDFQTLVDA AKDKSIPLQG AVLIGKDAEG SPVLVDTGNR
       61 LGRRGAAWGA GVGLAIGLFS PALLASAALG AATGALAGTF AHHRIKTGLA DKIGQALAAG
      121 RAVVIAVTEA QGRLEAGQAL ASSPMKSVAE LSRSTLRSLG AALREAMGKF NPDRTRLPLP
      181 QRRFGGVVGR TMAESVGDWS IVPSPFPPDD APNVLIVLID DAGFGGPDTF GGAIRTPTLS
      241 RLAQNGLIYN RFHVTAVCSP TRAALLTGRN HHRVGFGSVC EFPGPYPGYS AVRPRSCAAL
      301 PRILRDNGYV TGAFGKWHLT PDNVQGAAGP FDNWPLGWGF DHFWGFPSGA AGQYDPIISQ
      361 DNSVIGIPEG SGEDGRPYYF PDDLTDKAIE WLHTVRAQNA TKPWMLYYAT GATHAPHHVF
      421 KEWADKYRGE FDDGWDVYRQ KTFERQKRLG IIPPDAELTE RPDLFPAWDS MSEAQKRLFA
      481 RQMEVFAGFS ENADWNVGRL LDAIEDLGES DNTLVFYIWG DNGASMEGTN TGSFNEMTFL
      541 NGLDLDAERQ LELIEQYGGI AALGDEFTAP HFASAWAHAS NTPLQWGKQM ASHLGGTRDP
      601 LVVAWPARIR PDGRVRSQFT HCIDIAPTVL AAIGLPEPTH VDGFEQEPMD GTSFVRTFDD
      661 AEAEDRHTVQ YFENFGSRAI YKDGWWACAR LDKAPWDLSP ETMRRFAPGT YDPDQDVWEL
      721 YYLPDDFSQA KNLAAEHPDK VAELTQLWWQ EAERNRVLPL LGGLAVMFGD LPPLPTTARF
      781 SFKGDVQNIQ RGMVPRICGR SYAIEARLHI PDGGAQGVIV ANADFMGGFA LWVDEQRHLH
      841 HTYSFLGVET YRQVSSEPLP TGDVTVRMLF DSHQPVAASG GRVTLWADDR LIGEGELPQT
      901 VPLAFTSYAG MDIGRDNGLV VDRGYEDKAP YAFTGTVTEV IFDLKPVHPE AARALHEHAS
      961 VQAVGQGAAG
//