LOCUS       SIU01950.1               494 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE PCD (PIPERIDEINE-
            6-CARBOXYLATE DEHYDROGENASE) protein.
ACCESSION   LT708304-3364
PROTEIN_ID  SIU01950.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pcd"
                     /locus_tag="BQ2027_MB3321"
                     /note="Mb3321, pcd, len: 494 aa. Equivalent to Rv3293,
                     len: 494 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 494 aa overlap). Probable pcd,
                     piperideine-6-carboxylic acid dehydrogenase (EC 1.5.-.-),
                     highly similar to others e.g. O85725|PCD SEMIALDEHYDE
                     DEHYDROGENASE from Streptomyces clavuligerus (512 aa),
                     FASTA scores: opt: 2214, E(): 6.7e-121, (68.75% identity
                     in 496 aa overlap) (see first citation below);
                     Q9I4U7|PA1027 PROBABLE ALDEHYDE DEHYDROGENASE from
                     Pseudomonas aeruginosa (529 aa), FASTA scores: opt: 1984,
                     E(): 1.4e-107, (64.5% identity in 493 aa overlap);
                     BAB49892|MLL2867 ALDEHYDE DEHYDROGENASE from Rhizobium
                     loti (Mesorhizobium loti) (504 aa), FASTA scores: opt:
                     1964, E(): 2e-106, (62.8% identity in 476 aa overlap);
                     Q9A8Y1|CC1216 ALDEHYDE DEHYDROGENASE from Caulobacter
                     crescentus (507 aa), FASTA scores: opt: 1909, E():
                     3.1e-103, (59.95% identity in 497 aa overlap); O54199|PCD
                     PIPERIDEINE-6-CARBOXILIC ACID DEHYDROGENASE from
                     Streptomyces clavuligerus (496 aa), FASTA scores: opt:
                     1748, E(): 6.4e-94, (60.6% identity in 467 aa overlap);
                     and Q9F1U8|PCD PIPERIDEINE-6-CARBOXYLATE DEHYDROGENASE
                     from 'Flavobacterium' lutescens (510 aa), FASTA scores:
                     opt: 1656, E(): 1.4e-88, (54.05% identity in 481 aa
                     overlap) (see second citation below); etc. Contains
                     PS00687 Aldehyde dehydrogenases glutamic acid active site.
                     Note that ORF Rv3290c seems to encoded the putative lat
                     enzyme. Previously known as aldB. Protein product from
                     Mb3321 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb3321 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3Q7"
                     /db_xref="InterPro:IPR015590"
                     /db_xref="InterPro:IPR016161"
                     /db_xref="InterPro:IPR016162"
                     /db_xref="InterPro:IPR016163"
                     /db_xref="InterPro:IPR029510"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3Q7"
BEGIN
        1 MLEACQAIGV TAALGEPGEH SLPASTPITG DVLFSIAPTT PEQADHAIAA AAATFTAWRS
       61 TPAPVRGALV ARLGELLTAH QQDLATLVTV EVGKITAEAR GEVQEMIDVC QFSVGLSRQL
      121 YGRTIASERA GHRLLETWHP LGVVGVITAF NFPVAVWAWN TAVALVCGDT VVWKPSELTP
      181 LTALACQALL SRAAADVGAP AAVGGLLLGG AERGAQLVDD PRVALLSATG SVRMGQQVGP
      241 RVARRFGRVL LELGGNNAAI VAPSADLELA VRCIVFAAAG TAGQRCTSLR RLIVHRSVAD
      301 DVVARVVGAY RQLAIGDPSA PDTLVGPLIH EAAYRDMVAA LERARTDGGE VIGGDRREVG
      361 SPGAYYVAPA VVRMPSQTAI VATETFAPIL YVLTYDDLDE AIALNNAVPQ GLSSSIFTTD
      421 LREAEHFLDQ SDCGIANVNI GTSGAEIGGA FGGEKQTGGG RESGSDAWKA YMRRATNTVN
      481 YSSELPLAQG VKFG
//