LOCUS       SIU01940.1               297 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            THIOSULFATE SULFURTRANSFERASE SSEA (RHODANESE) (THIOSULFATE
            CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE)
            protein.
ACCESSION   LT708304-3354
PROTEIN_ID  SIU01940.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="sseA"
                     /locus_tag="BQ2027_MB3311"
                     /note="Mb3311, sseA, len: 297 aa. Equivalent to Rv3283,
                     len: 297 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 297 aa overlap). Probable sseA,
                     thiosulfate sulfurtransferase (EC 2.8.1.1), equivalent
                     P46700|THT2_MYCLE|SSEA|ML0728|B1308_C1_127 PUTATIVE
                     THIOSULFATE SULFURTRANSFERASE SSEA from Mycobacterium
                     leprae (296 aa), FASTA scores: opt: 1742, E(): 5.5e-108,
                     (83.45% identity in 296 aa overlap). Also highly similar
                     to others e.g. Q9RXT9|DR0217 from Deinococcus radiodurans
                     (286 aa), FASTA scores: opt: 1057, E(): 1.2e-62, (53.86%
                     identity in 273 aa overlap); P16385|THTR_SACER|CYSA from
                     Saccharopolyspora erythraea (Streptomyces erythraeus) (281
                     aa), FASTA scores: opt: 1006, E(): 2.7e-59, (51.25%
                     identity in 277 aa overlap); P71121|THTR_CORGL from
                     Corynebacterium glutamicum (Brevibacterium flavum) (225
                     aa), FASTA scores: opt: 897, E(): 3.6e-52, (59.05%
                     identity in 215 aa overlap); etc. Also highly similar to
                     O05793|CYSA1|CYSA|Rv3117|MT3199|MTCY164.27|CYSA2|RV0815c|M
                     T0837|MTV043.07c|THTR_MYCTU PUTATIVE THIOSULFATE
                     SULFURTRANSFERASE (EC 2.8.1.1) from Mycobacterium
                     tuberculosis (277 aa), FASTA scores: opt: 955, E():
                     6.3e-56, (50.2% identity in 271 aa overlap); and
                     Q50036|THTR_MYCLE|CYSA|CYSA3|ML2198 PUTATIVE THIOSULFATE
                     SULFURTRANSFERASE from Mycobacterium leprae (277 aa),
                     FASTA scores: opt: 931, E(): 2.5e-54, (48.9% identity in
                     276 aa overlap). Shows some similarity to MTCY339.19c
                     (30.3% identity in 254 aa overlap). Contains PS00683
                     Rhodanese C-terminal signature. BELONGS TO THE RHODANESE
                     FAMILY. Protein product from Mb3311 detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb3311
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:Q7TWT6"
                     /db_xref="InterPro:IPR001307"
                     /db_xref="InterPro:IPR001763"
                     /db_xref="InterPro:IPR036873"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TWT6"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MPLPADPSPT LSAYAHPERL VTADWLSAHM GAPGLAIVES DEDVLLYDVG HIPGAVKIDW
       61 HTDLNDPRVR DYINGEQFAE LMDRKGIARD DTVVIYGDKS NWWAAYALWV FTLFGHADVR
      121 LLNGGRDLWL AERRETTLDV PTKTCTGYPV VQRNDAPIRA FRDDVLAILD AQPLIDVRSP
      181 EEYTGKRTHM PDYPEEGALR AGHIPTAVHI PWGKAADESG RFRSREELER LYDFINPDDQ
      241 TVVYCRIGER SSHTWFVLTH LLGKADVRNY DGSWTEWGNA VRVPIVAGEE PGVVPVV
//