LOCUS       SIU01938.1               156 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            bifunctional protein acetyl-/propionyl-coenzyme a carboxylase
            (epsilon chain) acce5 protein.
ACCESSION   LT708304-3352
PROTEIN_ID  SIU01938.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="acce5"
                     /locus_tag="BQ2027_MB3309"
                     /note="Mb3309, -, len: 156 aa. Similar to Rv3281, len: 177
                     aa, from Mycobacterium tuberculosis strain H37Rv, (88.1%
                     identity in 177 aa overlap). Conserved hypothetical
                     protein, equivalent (but longer 14 aa and with a gap
                     between aa 82-102) to AAK47723|MT3380 from Mycobacterium
                     tuberculosis strain CDC1551 (142 aa), FASTA scores: opt:
                     830, E(): 3.1e-40, (86.5% identity in 163 aa overlap).
                     C-terminus highly similar to Q49671|B1308_C3_211|ML0730
                     from Mycobacterium leprae (84 aa), FASTA scores: opt: 393,
                     E(): 7.6e-16, (68.95% identity in 87 aa overlap).
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, an
                     in-frame deletion of 63 bp leads to a shorter product
                     compared to its homolog in Mycobacterium tuberculosis
                     strain H37Rv (156 aa versus 177 aa). Protein product from
                     Mb3309 detected using shotgun mass spectrometry. Mb3309
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="InterPro:IPR032716"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3Y2"
BEGIN
        1 MGTCPCESSE RNEPVSRVSG TNEVSDGNET NNPAEVSDGN ETNNPAEVSD GNETNNPAPV
       61 SRVSGTNEVS DGNETNNPAP VTEKPLHPHE PHIEILRGQP TDQELAALIA VLGSISGSTP
      121 PAQPEPTRWG LPVDQLRYPV FSWQRITLQE MTHMRR
//