LOCUS       SIU01935.1               172 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED TRANSMEMBRANE PROTEIN protein.
ACCESSION   LT708304-3349
PROTEIN_ID  SIU01935.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3306C"
                     /note="Mb3306c, -, len: 172 aa. Equivalent to Rv3278c,
                     len: 172 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.4% identity in 172 aa overlap). Probable conserved
                     transmembrane protein, equivalent to Q9CCL2|ML0733
                     PUTATIVE MEMBRANE PROTEIN from Mycobacterium leprae (172
                     aa), FASTA scores: opt: 1024, E(): 6e-61, (83.15% identity
                     in 172 aa overlap); and Q49672|B1308_F2_67 HYPOTHETICAL
                     PROTEIN from Mycobacterium leprae (181 aa), FASTA scores:
                     opt: 1024, E(): 6.3e-61, (83.15% identity in 172 aa
                     overlap) (this is certainly the same putative protein but
                     with N-terminus longer). Also some similarity to other
                     hypothetical proteins (generally membrane proteins) e.g.
                     O26822|MTH726 HYPOTHETICAL PROTEIN from Methanobacterium
                     thermoautotrophicum (204 aa), FASTA scores: opt: 147, E():
                     0.0079, (24.6% identity in 187 aa overlap); Q9X8H4|SCE9.01
                     HYPOTHETICAL 47.7 KDA PROTEIN (FRAGMENT) from Streptomyces
                     coelicolor (436 aa), FASTA scores: opt: 151, E(): 0.0079,
                     (28.1% identity in 153 aa overlap). Protein product from
                     Mb3306c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb3306c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y5H1"
                     /db_xref="InterPro:IPR005182"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5H1"
BEGIN
        1 MSYPENVLAA GEQVVLHRHP HWNRLIWPVV VLVLLTGLAA FGSGFVNSTP WQQIAKNVIH
       61 AVIWGIWLVI VGWLTLWPFL SWLTTHFVVT NRRVMFRHGV LTRSGIDIPL ARINSVEFRD
      121 RIFERIFRTG TLIIESASQD PLEFYNIPRL REVHALLYHK VFDTLGSDES PS
//