LOCUS       SIU01932.1               174 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC SUBUNIT
            PURE (AIR CARBOXYLASE) (AIRC) protein.
ACCESSION   LT708304-3346
PROTEIN_ID  SIU01932.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="purE"
                     /locus_tag="BQ2027_MB3303C"
                     /note="Mb3303c, purE, len: 174 aa. Equivalent to Rv3275c,
                     len: 174 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.4% identity in 174 aa overlap). Probable purE,
                     phosphoribosylaminoimidazole carboxylase catalytic subunit
                     (EC 4.1.1.21), equivalent to
                     P46702|PUR6_MYCLE|PURE|ML0736|B1308_F3_98 from
                     Mycobacterium leprae (171 aa), FASTA scores: opt: 878,
                     E(): 1.5e-43, (81.55% identity in 168 aa overlap). Also
                     similar to others e.g. Q9AXD0|AIRC from Nicotiana tabacum
                     (Common tobacco) (623 aa), FASTA scores: opt: 712, E():
                     1.4e-33, (69.35% identity in 160 aa overlap) (similarity
                     in C-terminal part for this one); Q44679|PUR6_CORAM from
                     Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
                     (177 aa), FASTA scores: opt: 651, E(): 1.5e-30, (68.25%
                     identity in 148 aa overlap);
                     Q55498|PUR6_SYNY3|PURE|SLL0901 from Synechocystis sp.
                     strain PCC 6803 (176 aa), FASTA scores: opt: 639, E():
                     7.1e-30, (60.5% identity in 167 aa overlap); etc. Protein
                     product from Mb3303c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3303c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y3M8"
                     /db_xref="InterPro:IPR000031"
                     /db_xref="InterPro:IPR024694"
                     /db_xref="InterPro:IPR033747"
                     /db_xref="InterPro:IPR035893"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3M8"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTPAGERPRV GVIMGSDSDW PVMADAAAAL AEFDIPAEVR VVSAHRTPEA MFSYARGAAE
       61 RGLEVIIAGA GGAAHLPGMV AAATPLPVIG VPVPLGRLDG LDSLLSIVQM PAGVPVATVS
      121 IGGARNAGLL AVRMLGAANP QLRARIVAFQ DRLADVVAAK DAELQRLAGK LTRD
//