LOCUS SIU01927.1 718 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE METAL CATION-TRANSPORTING P-TYPE ATPASE C CTPC protein. ACCESSION LT708304-3341 PROTEIN_ID SIU01927.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ctpC" /locus_tag="BQ2027_MB3298" /note="Mb3298, ctpC, len: 718 aa. Equivalent to Rv3270, len: 718 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 718 aa overlap). Probable ctpC, metal cation-transport ATPase P-type (EC 3.6.3.-), integral membrane protein, equivalent to Q9CCL1|CTPC|ML0747 PUTATIVE CATION TRANSPORT ATPASE from Mycobacterium leprae (725 aa), FASTA scores: opt: 3908, E(): 0, (85.95% identity in 713 aa overlap). Also similar to O66027|MTAA METAL TRANSPORTING ATPASE MTA72 from Mycobacterium tuberculosis (680 aa), FASTA scores: opt: 3756, E(): 5.5e-213, (91.45% identity in 679 aa overlap); and to other ATPases e.g. Q9ZHC7|SILP_SALTY PUTATIVE CATION TRANSPORTING P-TYPE ATPASE from Salmonella typhimurium (824 aa), FASTA scores: opt: 1145, E(): 1.3e-59, (36.55% identity in 643 aa overlap); Q9HX93|PA3920 PROBABLE METAL TRANSPORTING P-TYPE ATPASE from Pseudomonas aeruginosa (792 aa), FASTA scores: opt: 1140, E(): 2.4e-59, (35.95% identity in 745 aa overlap); etc. Contains PS00154 E1-E2 ATPases phosphorylation site. BELONGS TO THE CATION TRANSPORT ATPASES FAMILY (E1-E2 ATPASES), SUBFAMILY IB. Protein product from Mb3298 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3298 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:P0A503" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="UniProtKB/Swiss-Prot:P0A503" BEGIN 1 MTLEVVSDAA GRMRVKVDWV RCDSRRAVAV EEAVAKQNGV RVVHAYPRTG SVVVWYSPRR 61 ADRAAVLAAI KGAAHVAAEL IPARAPHSAE IRNTDVLRMV IGGVALALLG VRRYVFARPP 121 LLGTTGRTVA TGVTIFTGYP FLRGALRSLR SGKAGTDALV SAATVASLIL RENVVALTVL 181 WLLNIGEYLQ DLTLRRTRRA ISELLRGNQD TAWVRLTDPS AGSDAATEIQ VPIDTVQIGD 241 EVVVHEHVAI PVDGEVVDGE AIVNQSAITG ENLPVSVVVG TRVHAGSVVV RGRVVVRAHA 301 VGNQTTIGRI ISRVEEAQLD RAPIQTVGEN FSRRFVPTSF IVSAIALLIT GDVRRAMTML 361 LIACPCAVGL STPTAISAAI GNGARRGILI KGGSHLEQAG RVDAIVFDKT GTLTVGRPVV 421 TNIVAMHKDW EPEQVLAYAA SSEIHSRHPL AEAVIRSTEE RRISIPPHEE CEVLVGLGMR 481 TWADGRTLLL GSPSLLRAEK VRVSKKASEW VDKLRRQAET PLLLAVDGTL VGLISLRDEV 541 RPEAAQVLTK LRANGIRRIV MLTGDHPEIA QVVADELGID EWRAEVMPED KLAAVRELQD 601 DGYVVGMVGD GINDAPALAA ADIGIAMGLA GTDVAVETAD VALANDDLHR LLDVGDLGER 661 AVDVIRQNYG MSIAVNAAGL LIGAGGALSP VLAAILHNAS SVAVVANSSR LIRYRLDR //