LOCUS SIU01921.1 359 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 d-alpha-
d-mannose-1-phosphate guanylyltransferase manb (d-alpha-
d-heptose-1-phosphate guanylyltransferase) protein.
ACCESSION LT708304-3335
PROTEIN_ID SIU01921.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="manC"
/locus_tag="BQ2027_MB3292C"
/note="Mb3292c, manC, len: 359 aa. Equivalent to Rv3264c,
len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 359 aa overlap). Probable manC,
mannose-1-phosphate guanyltransferase (EC 2.7.7.22),
equivalent to Q9CCK6|RMLA2|ML0753 PUTATIVE SUGAR-PHOSPHATE
NUCLEOTIDYL TRANSFERASE from Mycobacterium leprae (358
aa), FASTA scores: opt: 2075, E(): 2.7e-115, (86.9%
identity in 359 aa overlap). Also similar to others e.g.
Q9KZK6|SCE34.20c PUTATIVE NUCLEOTIDE PHOSPHORYLASE from
Streptomyces coelicolor (360 aa), FASTA scores: opt: 1314,
E(): 2.2e-70, (57.0% identity in 358 aa overlap);
Q9KZP4|SC1A8A.08 PUTATIVE MANNOSE-1-PHOSPHATE
GUANYLTRANSFERASE from Streptomyces coelicolor (831 aa),
FASTA scores: opt: 699, E(): 8.6e-34, (34.45% identity in
354 aa overlap) (only similarity in N-terminus for this
one); P74589|SLL1496 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE
from Synechocystis sp. strain PCC 6803 (843 aa), FASTA
scores: opt: 692, E(): 2.3e-33, (35.1% identity in 342 aa
overlap) (only similarity in N-terminus for this one too);
BAB59222|TVG0079558 MANNOSE-1-PHOSPHATE GUANYLTRANSFERASE
from Thermoplasma volcanium (359 aa), FASTA scores: opt:
664, E(): 5.2e-32, (34.6% identity in 338 aa overlap);
Q9ZTW5|GMP GDP-MANNOSE PYROPHOSPHORYLASE from Solanum
tuberosum (Potato) (361 aa), FASTA scores: opt: 636, E():
2.3e-30, (34.65% identity in 361 aa overlap); etc. BELONGS
TO FAMILY 2 OF MANNOSE-6-PHOSPHATE ISOMERASES. Note that
previously known as rmlA2. Protein product from Mb3292c
detected using shotgun mass spectrometry and SWATH mass
spectrometry. Mb3292c found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:A0A1R3Y3L4"
/db_xref="InterPro:IPR001451"
/db_xref="InterPro:IPR005835"
/db_xref="InterPro:IPR029044"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y3L4"
BEGIN
1 MATHQVDAVV LVGGKGTRLR PLTLSAPKPM LPTAGLPFLT HLLSRIAAAG IEHVILGTSY
61 KPAVFEAEFG DGSALGLQIE YVTEEHPLGT GGGIANVAGK LRNDTAMVFN GDVLSGADLA
121 QLLDFHRSNR ADVTLQLVRV GDPRAFGCVP TDEEDRVVAF LEKTEDPPTD QINAGCYVFE
181 RNVIDRIPQG REVSVEREVF PALLADGDCK IYGYVDASYW RDMGTPEDFV RGSADLVRGI
241 APSPALRGHR GEQLVHDGAA VSPGALLIGG TVVGRGAEIG PGTRLDGAVI FDGVRVEAGC
301 VIERSIIGFG ARIGPRALIR DGVIGDGADI GARCELLSGA RVWPGVFLPD GGIRYSSDV
//