LOCUS       SIU01917.1                89 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSCRIPTIONAL REGULATORY PROTEIN WHIB-LIKE WHIB2 protein.
ACCESSION   LT708304-3331
PROTEIN_ID  SIU01917.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="whiB2"
                     /locus_tag="BQ2027_MB3288C"
                     /note="Mb3288c, whiB2, len: 89 aa. Equivalent to Rv3260c,
                     len: 89 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 89 aa overlap). Probable whiB2,
                     WhiB-like regulatory protein (see first citation below),
                     similar to WhiB paralogue of Streptomyces coelicolor, wblE
                     gene product (85 aa). Equivalent to Q9CCK0|WHIB2|ML0760
                     PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium
                     leprae (89 aa), FASTA scores: opt: 550, E(): 6.1e-31,
                     (85.4% identity in 89 aa overlap). Also similar to others
                     e.g. Q9S426 WHMD REGULATORY PROTEIN (see second citation
                     below) from Mycobacterium smegmatis (129 aa), FASTA
                     scores: opt: 488, E(): 1.4e-26, (83.55% identity in 85 aa
                     overlap); Q06387|WHIB-STV WHIB-STV PROTEIN from
                     Streptomyces griseocarneus (87 aa), FASTA scores: opt:
                     443, E(): 1.2e-23, (74.7% identity in 83 aa overlap);
                     Q05429|WHIB|WHIB1 TRANSCRIPTION-LIKE FACTOR WHIB from
                     Streptomyces aureofaciens (87 aa), FASTA scores: opt: 442,
                     E(): 1.3e-23, (74.7% identity in 83 aa overlap); etc.
                     Equivalent to AAK47700 WhiB-related protein from
                     Mycobacterium tuberculosis strain CDC1551 (123 aa) but
                     shorter 34 aa. Also similar to other Mycobacterium
                     tuberculosis proteins: MTCY07D11.07c (45.1% identity in 71
                     aa overlap) and MTCY78.13c (37.4% identity in 91 aa
                     overlap). Start chosen by homology but ORF continues to
                     ATG upstream at 3754. Mb3288c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3S0"
                     /db_xref="InterPro:IPR003482"
                     /db_xref="InterPro:IPR034768"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3S0"
BEGIN
        1 MVPEAPAPFE EPLPPEATDQ WQDRALCAQT DPEAFFPEKG GSTREAKKIC MGCEVRHECL
       61 EYALAHDERF GIWGGLSERE RRRLKRGII
//