LOCUS SIU01914.1 465 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable phosphomannomutase pmma (pmm) (phosphomannose mutase) protein. ACCESSION LT708304-3328 PROTEIN_ID SIU01914.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="pmma" /locus_tag="BQ2027_MB3285C" /note="Mb3285c, manB, len: 465 aa. Equivalent to Rv3257c, len: 465 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 465 aa overlap). Probable manB, phosphomannomutase (EC 5.4.2.8) (see citation below), equivalent to Q9CCJ7|PMMA|ML0763 from Mycobacterium leprae (468 aa), FASTA scores: opt: 2533, E(): 2e-145, (83.1% identity in 468 aa overlap). Also similar to many e.g. Q9KZL6|MANB from Streptomyces coelicolor (454 aa), FASTA scores: opt: 1820, E(): 2e-102, (63.2% identity in 459 aa overlap); Q9PGN8|XF0260 from Xylella fastidiosa (500 aa), FASTA scores: opt: 1085, E(): 4.7e-58, (40.7% identity in 462 aa overlap); Q9EY19|MANB from Salmonella enterica subsp. arizonae (456 aa), FASTA scores: opt: 988, E(): 3.1e-52, (38.65% identity in 445 aa overlap); etc. BELONGS TO THE PHOSPHOHEXOSE MUTASES FAMILY. Note that previously known as pmmA. Protein product from Mb3285c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3285c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y3K8" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR036900" /db_xref="UniProtKB/TrEMBL:A0A1R3Y3K8" BEGIN 1 MSWPAAAVDR VIKAYDVRGL VGEEIDESLV TDLGAAFARL MRTEDARPVV IGHDMRDSSP 61 SLADAFAAGV TGQGLDVVRV GLASTDQLYF ASGLLDCPGA MFTASHNPAA YNGIKMCRAA 121 AKPVGADTGL TAIRDDLIAG VARYDGTPGT IADQDVLVDY GAFLRSLVDT SGLRPLRVAV 181 DAGNGMAGHT APAVLGVIDS ITLLPLYFEL DGSFPNHEAN PLDPANLVDL QAYVRDTGAD 241 IGLAFDGDAD RCFVVDERGQ PVSPSTVTAL VAARELNREI GATIIHNVIT SRAVPELVAE 301 RGGTPLRSRV GHSYIKALMA ETGAIFGGEH SAHYYFRDFW GADSGMLAAL HVLAALGEQS 361 RPLSELTADY QRYESSGEIN FTVVDSSACV EAVLKSFGNR IVSIDHLDGV TVDLGDDSWF 421 NLRSSNTEPL LRLNVEGRSV GDVDAVVRQV SAEIAAQSAH AKAGP //