LOCUS       SIU01914.1               465 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            phosphomannomutase pmma (pmm) (phosphomannose mutase)
            protein.
ACCESSION   LT708304-3328
PROTEIN_ID  SIU01914.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pmma"
                     /locus_tag="BQ2027_MB3285C"
                     /note="Mb3285c, manB, len: 465 aa. Equivalent to Rv3257c,
                     len: 465 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 465 aa overlap). Probable manB,
                     phosphomannomutase (EC 5.4.2.8) (see citation below),
                     equivalent to Q9CCJ7|PMMA|ML0763 from Mycobacterium leprae
                     (468 aa), FASTA scores: opt: 2533, E(): 2e-145, (83.1%
                     identity in 468 aa overlap). Also similar to many e.g.
                     Q9KZL6|MANB from Streptomyces coelicolor (454 aa), FASTA
                     scores: opt: 1820, E(): 2e-102, (63.2% identity in 459 aa
                     overlap); Q9PGN8|XF0260 from Xylella fastidiosa (500 aa),
                     FASTA scores: opt: 1085, E(): 4.7e-58, (40.7% identity in
                     462 aa overlap); Q9EY19|MANB from Salmonella enterica
                     subsp. arizonae (456 aa), FASTA scores: opt: 988, E():
                     3.1e-52, (38.65% identity in 445 aa overlap); etc. BELONGS
                     TO THE PHOSPHOHEXOSE MUTASES FAMILY. Note that previously
                     known as pmmA. Protein product from Mb3285c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb3285c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3K8"
                     /db_xref="InterPro:IPR005841"
                     /db_xref="InterPro:IPR005843"
                     /db_xref="InterPro:IPR005844"
                     /db_xref="InterPro:IPR005845"
                     /db_xref="InterPro:IPR005846"
                     /db_xref="InterPro:IPR016055"
                     /db_xref="InterPro:IPR036900"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3K8"
BEGIN
        1 MSWPAAAVDR VIKAYDVRGL VGEEIDESLV TDLGAAFARL MRTEDARPVV IGHDMRDSSP
       61 SLADAFAAGV TGQGLDVVRV GLASTDQLYF ASGLLDCPGA MFTASHNPAA YNGIKMCRAA
      121 AKPVGADTGL TAIRDDLIAG VARYDGTPGT IADQDVLVDY GAFLRSLVDT SGLRPLRVAV
      181 DAGNGMAGHT APAVLGVIDS ITLLPLYFEL DGSFPNHEAN PLDPANLVDL QAYVRDTGAD
      241 IGLAFDGDAD RCFVVDERGQ PVSPSTVTAL VAARELNREI GATIIHNVIT SRAVPELVAE
      301 RGGTPLRSRV GHSYIKALMA ETGAIFGGEH SAHYYFRDFW GADSGMLAAL HVLAALGEQS
      361 RPLSELTADY QRYESSGEIN FTVVDSSACV EAVLKSFGNR IVSIDHLDGV TVDLGDDSWF
      421 NLRSSNTEPL LRLNVEGRSV GDVDAVVRQV SAEIAAQSAH AKAGP
//