LOCUS       SIU01904.1               214 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 thymidylate
            kinase tmk (dtmp kinase) (thymidylic acid kinase) (tmpk)
            protein.
ACCESSION   LT708304-3318
PROTEIN_ID  SIU01904.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="tmk"
                     /locus_tag="BQ2027_MB3275C"
                     /note="Mb3275c, tmk, len: 214 aa. Equivalent to Rv3247c,
                     len: 214 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 214 aa overlap). Probable tmk,
                     thymidylate kinase (EC 2.7.4.9), equivalent to
                     Q9CCJ3|TMK|ML0772 PUTATIVE THYMIDYLATE KINASE from
                     Mycobacterium leprae (210 aa), FASTA scores: opt: 1023,
                     E(): 4.8e-57, (77.3% identity in 207 aa overlap). Also
                     similar to other thymidylate kinases e.g.
                     Q9RQJ9|KTHY_CAUCR|TMK|CC1824 from Caulobacter crescentus
                     (208 aa), FASTA scores: opt: 179, E(): 0.0003, (31.3%
                     identity in 214 aa overlap); Q9V1E9|KTHY_PYRAB|TMK|PAB0319
                     from Pyrococcus abyssi (205 aa), FASTA scores: opt: 176,
                     E(): 0.00045, (29.1% identity in 189 aa overlap); etc.
                     BELONGS TO THE THYMIDYLATE KINASE FAMILY. Protein product
                     from Mb3275c detected using SWATH mass spectrometry.
                     Mb3275c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3J9"
                     /db_xref="InterPro:IPR018094"
                     /db_xref="InterPro:IPR018095"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR039430"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3J9"
BEGIN
        1 MLIAIEGVDG AGKRTLVEKL SGAFRAAGRS VATLAFPRYG QSVAADIAAE ALHGEHGDLA
       61 SSVYAMATLF ALDRAGAVHT IQGLCRGYDV VILDRYVASN AAYSAARLHE NAAGKAAAWV
      121 QRIEFARLGL PKPDWQVLLA VSAELAGERS RGRAQRDPGR ARDNYERDAE LQQRTGAVYA
      181 ELAAQGWGGR WLVVGADVDP GRLAATLAPP DVPS
//