LOCUS       SIU01902.1               567 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 TWO
            COMPONENT SENSORY TRANSDUCTION HISTIDINE KINASE MTRB protein.
ACCESSION   LT708304-3316
PROTEIN_ID  SIU01902.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mtrB"
                     /locus_tag="BQ2027_MB3273C"
                     /note="Mb3273c, mtrB, len: 567 aa. Equivalent to Rv3245c,
                     len: 567 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 567 aa overlap). mtrB, sensor-like
                     histidine kinase (EC 2.7.3.-) (see citations below),
                     equivalent to Q9CCJ1|MTRB OR ML0774 PUTATIVE TWO-COMPONENT
                     SYSTEM SENSOR KINASE from Mycobacterium leprae (562 aa),
                     FASTA scores: opt: 3208, E(): 7.4e-173, (88.7% identity in
                     566 aa overlap). Also similar to others e.g.
                     Q9KYW9|SCE33.14c PUTATIVE TWO-COMPONENT SYSTEM HISTIDINE
                     KINASE from Streptomyces coelicolor (688 aa), FASTA
                     scores: opt: 1355, E(): 1.1e-68, (48.95% identity in 515
                     aa overlap); etc. Relatives in Mycobacterium tuberculosis
                     are: MTCY369.03, E(): 1.5e-22; MTCY20G9.16, E(): 1.9e-17.
                     SIMILAR TO OTHER PROKARYOTIC SENSORY TRANSDUCTION
                     HISTIDINE KINASES. Protein product from Mb3273c detected
                     using SWATH mass spectrometry. Mb3273c found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P59963"
                     /db_xref="InterPro:IPR003594"
                     /db_xref="InterPro:IPR003660"
                     /db_xref="InterPro:IPR003661"
                     /db_xref="InterPro:IPR004358"
                     /db_xref="InterPro:IPR005467"
                     /db_xref="InterPro:IPR036097"
                     /db_xref="InterPro:IPR036890"
                     /db_xref="UniProtKB/Swiss-Prot:P59963"
BEGIN
        1 MIFGSRRRIR GRRGRSGPMT RGLSALSRAV AVAWRRSLQL RVVALTLGLS LAVILALGFV
       61 LTSQVTNRVL DIKVRAAIDQ IERARTTVSG IVNGEETRSL DSSLQLARNT LTSKTDPASG
      121 AGLAGAFDAV LMVPGDGPRA ASTAGPVDQV PNALRGFVKA GQAAYQYATV QTEGFSGPAL
      181 IIGTPTLSRV ANLELYLIFP LASEQATITL VRGTMATGGL VLLVLLAGIA LLVSRQVVVP
      241 VRSASRIAER FAEGHLSERM PVRGEDDMAR LAVSFNDMAE SLSRQIAQLE EFGNLQRRFT
      301 SDVSHELRTP LTTVRMAADL IYDHSADLDP TLRRSTELMV SELDRFETLL NDLLEISRHD
      361 AGVAELSVEA VDLRTTVNNA LGNVGHLAEE AGIELLVDLP AEQVIAEVDA RRVERILRNL
      421 IANAIDHAEH KPVRIRMAAD EDTVAVTVRD YGVGLRPGEE KLVFSRFWRS DPSRVRRSGG
      481 TGLGLAISVE DARLHQGRLE AWGEPGEGAC FRLTLPLVRG HKVTTSPLPM KPIPQPVLQP
      541 VAQPNPQPMP PEYKERQRPR EHAEWSG
//