LOCUS       SIU01895.1               244 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED INTEGRAL MEMBRANE PROTEIN protein.
ACCESSION   LT708304-3309
PROTEIN_ID  SIU01895.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3266C"
                     /note="Mb3266c, -, len: 244 aa. Equivalent to Rv3238c,
                     len: 244 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 244 aa overlap). Probable conserved
                     integral membrane protein, similar to several hypothetical
                     proteins and transmembrane proteins e.g. Q9UN92|NRM29
                     MULTISPANNING NUCLEAR ENVELOPE MEMBRANE PROTEIN NURIM
                     (FRAGMENT) from Homo sapiens (Human) (261 aa), FASTA
                     scores: opt: 281, E(): 3.3e-11, (30.7% identity in 189 aa
                     overlap); Q9VEG9|CG7655 HYPOTHETICAL PROTEIN from
                     Drosophila melanogaster (Fruit fly) (253 aa), FASTA
                     scores: opt: 242, E(): 1.1e-08, (27.7% identity in 242 aa
                     overlap); BAB48937|MLR1600 HYPOTHETICAL PROTEIN from
                     Rhizobium loti (Mesorhizobium loti) (222 aa), FASTA
                     scores: opt: 137, E(): 0.066, (28.1% identity in 185 aa
                     overlap); BAB57936|SAV1774 AESENICAL PUMP MEMBRANE PROTEIN
                     HOMOLOG from Staphylococcus aureus subsp. aureus Mu50 (430
                     aa), FASTA scores: opt: 125, E(): 0.68, (25.7% identity in
                     144 aa overlap); etc. Protein product from Mb3266c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3266c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y5B6"
                     /db_xref="InterPro:IPR009915"
                     /db_xref="InterPro:IPR033580"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y5B6"
BEGIN
        1 MKRYLTIIYG AASYLVFLVA FGYAIGFVGD VVVPRTVDHA IAAPIGQAVV VNLVLLGVFA
       61 VQHSVMARQG FKRWWTRFVP PSIERSTYVL LASVALLLLY WQWRTMPAVI WDVRQPAGRV
      121 ALWALFWLGW ATVLTSTFMI NHFELFGLRQ VYLAWRGKPY TEIGFQAHLL YRWVRHPIML
      181 GFVVAFWATP MMTAGHLLFA IGATGYILVA LQFEERDLLA ALGDQYRDYR REVSMLLPWP
      241 HRHT
//