LOCUS       SIU01891.1               469 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 possible
            triacylglycerol synthase (diacylglycerol acyltransferase)
            protein.
ACCESSION   LT708304-3305
PROTEIN_ID  SIU01891.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="tgs3"
                     /locus_tag="BQ2027_MB3262C"
                     /note="Mb3262c, -, len: 469 aa. Equivalent to Rv3234c and
                     Rv3233c, len: 271 aa and 196 aa, from Mycobacterium
                     tuberculosis strain H37Rv, (100.0% identity in 266 aa
                     overlap and 100.0% identity in 196 aa overlap). Rv3234c:
                     Hypothetical protein, similar to C-terminus of
                     Mycobacterium tuberculosis hypothetical proteins e.g.
                     P71694|Rv1425|MTCY21B4.43|MTCY493.29c (459 aa), FASTA
                     scores: opt: 498, E(): 5.2e-24, (36.8% identity in 261 aa
                     overlap); MTCY03A2.28; MTCY31.23; MTCY493_29; MTCY28_26;
                     MTV013_8; MTY13E12_33; etc. Also similar to
                     Q9X7A8|MLCB1610.05|ML1244 CONSERVED MEMBRANE PROTEIN from
                     Mycobacterium leprae (491 aa), FASTA scores: opt: 309,
                     E(): 4.3e-12, (33.35% identity in 189 aa overlap).
                     Rv3233c: Hypothetical protein, similar to C-terminus of
                     Q9RIU8|SCM11.13c HYPOTHETICAL 47.1 KDA PROTEIN from
                     Streptomyces coelicolor (446 aa), FASTA scores: opt: 308,
                     E(): 1.2e-12, (32.0% identity in 200 aa overlap); and
                     several hypothetical Mycobacterium tuberculosis proteins
                     e.g. O06343|YY80_MYCTU|Rv3480c|MTCY13E12.33c (497 aa),
                     FASTA scores: opt: 248, E(): 9.8e-09, (27.5% identity in
                     200 aa overlap); MTCY28_26; MTCY493_29; MTCY31_25;
                     MTCY31_25. REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis H37Rv, Rv3234c and Rv3233c exist as 2 genes.
                     In Mycobacterium bovis, a single base insertion (*-g)
                     leads to a single product that is more similar to Rv3234c.
                     Protein product from Mb3262c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3262c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3I4"
                     /db_xref="InterPro:IPR004255"
                     /db_xref="InterPro:IPR009721"
                     /db_xref="InterPro:IPR014292"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3I4"
BEGIN
        1 MVTRLSASDA SFYQLENTAT PMYVGLLLIL RRPRAGLSYE ALLETVEQRL PQIPRYRQKV
       61 QEVKLGLARP VWIDDRDFDI TYHVRRSALP SPGSDEQLHE LIARLAARPL DKSRPLWEMY
      121 LVEGLEKNRI ALYTKSHQAL INGVTALAIG HVIADRTRRP PAFPEDIWVP ERDPGTTRLL
      181 LRAVGDWLVR PGAQLQAVGS AVAGLVTNSG QLVETGRKVL DIARTVARGT APSSPLNATV
      241 SRNRRFTVAR ASLDDYRTVR ARYDCDVHDV VLTVIAGALG NWLMSRGEAV APTATVRAMA
      301 PLSVYADDQL DSTGPGQAIS QVTPFLVDLP VGEGNAVVRL SQIAHATESN PTAASLVDAR
      361 TIVTLSGLAP ATLHAMGVRV ATSFSARLFN LLITNAPGTQ SQMYIAGTKL LETYSVPPLL
      421 HNQALAISVT SYNGMLYFGI NADRDAMSDV DLLPGLLSQA LDELLEASR
//