LOCUS       SIU01885.1               450 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 3-PHOSPHOSHIKIMAT
            E 1-CARBOXYVINYLTRANSFERASE AROA (5-ENOLPYRUVYLSHIKIMATE-
            3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS) protein.
ACCESSION   LT708304-3299
PROTEIN_ID  SIU01885.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="aroA"
                     /locus_tag="BQ2027_MB3256"
                     /note="Mb3256, aroA, len: 450 aa. Equivalent to Rv3227,
                     len: 450 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 450 aa overlap). aroA,
                     3-phosphoshikimate 1-carboxyvinyl transferase (EC
                     2.5.1.19) (see citation below), equivalent (but C-terminus
                     longer) to Q9CCI3|AROA|ML0792 PUTATIVE 3-PHOSPHOSHIKIMATE
                     1-CARBOXYVINYL TRANSFERASE from Mycobacterium leprae (430
                     aa), FASTA scores: opt: 1466, E(): 1.4e-78, (55.05%
                     identity in 427 aa overlap). Contains PS00885 EPSP
                     synthase signature 2. BELONGS TO THE EPSP SYNTHASE FAMILY.
                     Protein product from Mb3256 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3256 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:Q7TWY4"
                     /db_xref="InterPro:IPR001986"
                     /db_xref="InterPro:IPR006264"
                     /db_xref="InterPro:IPR013792"
                     /db_xref="InterPro:IPR023193"
                     /db_xref="InterPro:IPR036968"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TWY4"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MKTWPAPTAP TPVRATVTVP GSKSQTNRAL VLAALAAAQG RGASTISGAL RSRDTELMLD
       61 ALQTLGLRVD GVGSELTVSG RIEPGPGARV DCGLAGTVLR FVPPLAALGS VPVTFDGDQQ
      121 ARGRPIAPLL DALRELGVAV DGTGLPFRVH GNGSLAGGTV AIDASASSQF VSGLLLSAAS
      181 FTDGLTVQHT GSSLPSAPHI AMTAAMLRQA GVDIDDSTPN RWQVRPGPVA ARRWDIEPDL
      241 TNAVAFLSAA VVSGGTVRIT GWPRVSVQPA DHILAILRQL NAVVIHADSS LEVRGPTGYD
      301 GFDVDLRAVG ELTPSVAALA ALASPGSVSR LSGIAHLRGH ETDRLAALST EINRLGGTCR
      361 ETPDGLVITA TPLRPGIWRA YADHRMAMAG AIIGLRVAGV EVDDIAATTK TLPEFPRLWA
      421 EMVGPGQGWG YPQPRSGQRA RRATGQGSGG
//