LOCUS SIU01862.1 228 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY)
protein.
ACCESSION LT708304-3276
PROTEIN_ID SIU01862.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/locus_tag="BQ2027_MB3233"
/note="Mb3233, -, len: 228 aa. Equivalent to Rv3208, len:
228 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 228 aa overlap). Probable
transcriptional regulator tetR family, equivalent to
Q9CCH0|ML0815 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL
REGULATOR from Mycobacterium leprae (228 aa), FASTA
scores: opt: 1248, E(): 1.4e-74, (82.4% identity in 227 aa
overlap). Also highly similar to Q9FBI8|SCP8.33c PUTATIVE
TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces
coelicolor (213 aa), FASTA scores: opt: 629, E(): 4e-34,
(45.8% identity in 203 aa overlap); Q9KIL9|F58R F58R
(FRAGMENT) from Streptomyces coelicolor A3(2) (149 aa),
FASTA scores: opt: 497, E(): 1.3e-25, (50.35% identity in
147 aa overlap); Q9K3T5|SCE66.08 PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor
(225 aa), FASTA scores: opt: 344, E(): 1.8e-15, (31.15%
identity in 212 aa overlap); Q9RYK4|DRA0308
TRANSCRIPTIONAL REGULATOR, TETR FAMILY from Deinococcus
radiodurans (239 aa), FASTA scores: opt: 290, E():
6.5e-12, (30.5% identity in 223 aa overlap); etc. And also
similar to Mycobacterium tuberculosis proteins
P96381|Rv1019|MTCY10G2.30c HYPOTHETICAL 21.7 KDA PROTEIN
(197 aa), FASTA scores: opt: 356, E(): 2.7e-16, (34.4%
identity in 189 aa overlap); MTV034_4; MTY07A7A_3;
MTV032_1; MTCY07A7_12; etc. Contains probable
helix-turn-helix motif at aa 60-81 (Score 1517, +4.35 SD).
SIMILAR TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL
REGULATORS. Protein product from Mb3233 detected using
shotgun mass spectrometry and SWATH mass spectrometry.
Mb3233 found to be expressed during exponential growth in
Sauton's minimal media by RNA-sequencing."
/db_xref="GOA:A0A1R3Y3F4"
/db_xref="InterPro:IPR001647"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR036271"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y3F4"
/experiment="experimental evidence, no additional details
recorded"
BEGIN
1 MSDLAKTAQR RALRSSGSAR PDEDVPAPNR RGNRLPRDER RGQLLVVASD VFVDRGYHAA
61 GMDEIADRAG VSKPVLYQHF SSKLELYLAV LHRHVENLVS GVHQALSTTT DNRQRLHVAV
121 QAFFDFIEHD SQGYRLIFEN DFVTEPEVAA QVRVATESCI DAVFALISAD SGLDPHRARM
181 IAVGLVGMSV DCARYWLDAD KPISKSDAVE GTVQFAWGGL SHVPLTRS
//