LOCUS       SIU01860.1               391 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE
            SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) protein.
ACCESSION   LT708304-3274
PROTEIN_ID  SIU01860.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="moeB1"
                     /locus_tag="BQ2027_MB3231C"
                     /standard_name="moeZ"
                     /note="Mb3231c, moeB1, len: 391 aa. Equivalent to Rv3206c,
                     len: 392 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 392 aa overlap). Probable moeB1,
                     molybdopterin cofactor biosynthesis protein, equivalent to
                     Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN
                     MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395
                     aa), FASTA scores: opt: 2285, E(): 3.3e-130, (86.45%
                     identity in 391 aa overlap.) Very similar to members of
                     the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE
                     SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA
                     scores: opt: 1776, E(): 1.4e-99, (65.3% identity in 395 aa
                     overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE
                     SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas
                     perfectomarina) (391 aa), FASTA scores: opt: 1526, E():
                     1.5e-84, (59.1% identity in 391 aa overlap);
                     O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from
                     Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2)
                     (391 aa), FASTA scores: opt: 1309, E(): 1.8e-71, (52.95%
                     identity in 387 aa overlap); P74344|MOEB|SLL1536
                     MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN from Synechocystis
                     sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1308,
                     E(): 2e-71, (50.65% identity in 397 aa overlap); etc. Also
                     highly similar to O05792|MOEB2|Rv3116|MTCY164.26 PUTATIVE
                     MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from
                     Mycobacterium tuberculosis (389 aa), FASTA scores: opt:
                     1440, E(): 2.3e-79, (57.25% identity in 386 aa overlap).
                     Has hydrophobic segment from ~45-71. BELONGS TO THE HesA
                     /MoeB/ThiF FAMILY. Note that previously known as moeZ.
                     Protein product from Mb3231c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3231c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y3H4"
                     /db_xref="InterPro:IPR000594"
                     /db_xref="InterPro:IPR001763"
                     /db_xref="InterPro:IPR035985"
                     /db_xref="InterPro:IPR036873"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3H4"
BEGIN
        1 MSTSLPPLVE PASALSREEV ARYSRHLIIP DLGVDGQKRL KNARVLVIGA GGLGAPTLLY
       61 LAAAGVGTIG IVDFDVVDES NLQRQVIHGV ADVGRSKAQS ARDSIVAINP LIRVRLHELR
      121 LAPSNAVDLF KQYDLILDGT DNFATRYLVN DAAVLAGKPY VWGSIYRFEG QASVFWEDAP
      181 DGLGVNYRDL YPEPPPGMVP SCAEGGVLGI ICASVASVMG TEAIKLITGI GETLLGRLLV
      241 YDALEMSYRT ITIRKDPSTP KITELVDYEQ FCGVVADDAA QAAKGSTITP RELRDWLDSG
      301 RKLALIDVRD PVEWDIVHID GAQLIPKSLI NSGEGLAKLP QDRTAVLYCK TGVRSAEALA
      361 AVKKAGFSDA VHLQGGIVAW AKQMQPDMVM Y
//