LOCUS SIU01860.1 391 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) protein. ACCESSION LT708304-3274 PROTEIN_ID SIU01860.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="moeB1" /locus_tag="BQ2027_MB3231C" /standard_name="moeZ" /note="Mb3231c, moeB1, len: 391 aa. Equivalent to Rv3206c, len: 392 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 392 aa overlap). Probable moeB1, molybdopterin cofactor biosynthesis protein, equivalent to Q9CCG8|MOEZ|ML0817 PROTEIN PROBABLY INVOLVED IN MOLYBDOPTERIN BIOSYNTHESIS from Mycobacterium leprae (395 aa), FASTA scores: opt: 2285, E(): 3.3e-130, (86.45% identity in 391 aa overlap.) Very similar to members of the HESA/MOEB/THIF family e.g. Q9FCL0|2SC3B6.02 PUTATIVE SULFURYLASE from Streptomyces coelicolor (392 aa), FASTA scores: opt: 1776, E(): 1.4e-99, (65.3% identity in 395 aa overlap); Q9XC37|PDTORFF MOEB-LIKE PROTEIN (PUTATIVE SULFURYLASE) from Pseudomonas stutzeri (Pseudomonas perfectomarina) (391 aa), FASTA scores: opt: 1526, E(): 1.5e-84, (59.1% identity in 391 aa overlap); O54307|MPT|MOEB MPT-SYNTHASE SULFURYLASE from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (391 aa), FASTA scores: opt: 1309, E(): 1.8e-71, (52.95% identity in 387 aa overlap); P74344|MOEB|SLL1536 MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN from Synechocystis sp. strain PCC 6803 (392 aa), FASTA scores: opt: 1308, E(): 2e-71, (50.65% identity in 397 aa overlap); etc. Also highly similar to O05792|MOEB2|Rv3116|MTCY164.26 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Mycobacterium tuberculosis (389 aa), FASTA scores: opt: 1440, E(): 2.3e-79, (57.25% identity in 386 aa overlap). Has hydrophobic segment from ~45-71. BELONGS TO THE HesA /MoeB/ThiF FAMILY. Note that previously known as moeZ. Protein product from Mb3231c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3231c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y3H4" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR035985" /db_xref="InterPro:IPR036873" /db_xref="UniProtKB/TrEMBL:A0A1R3Y3H4" BEGIN 1 MSTSLPPLVE PASALSREEV ARYSRHLIIP DLGVDGQKRL KNARVLVIGA GGLGAPTLLY 61 LAAAGVGTIG IVDFDVVDES NLQRQVIHGV ADVGRSKAQS ARDSIVAINP LIRVRLHELR 121 LAPSNAVDLF KQYDLILDGT DNFATRYLVN DAAVLAGKPY VWGSIYRFEG QASVFWEDAP 181 DGLGVNYRDL YPEPPPGMVP SCAEGGVLGI ICASVASVMG TEAIKLITGI GETLLGRLLV 241 YDALEMSYRT ITIRKDPSTP KITELVDYEQ FCGVVADDAA QAAKGSTITP RELRDWLDSG 301 RKLALIDVRD PVEWDIVHID GAQLIPKSLI NSGEGLAKLP QDRTAVLYCK TGVRSAEALA 361 AVKKAGFSDA VHLQGGIVAW AKQMQPDMVM Y //