LOCUS       SIU01855.1              1055 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            ATP-DEPENDENT DNA HELICASE protein.
ACCESSION   LT708304-3269
PROTEIN_ID  SIU01855.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3227C"
                     /note="Mb3227c, -, len: 1055 aa. Equivalent to Rv3202c,
                     len: 1055 aa, from Mycobacterium tuberculosis strain
                     H37Rv, (99.9% identity in 1055 aa overlap). Possible
                     ATP-dependent DNA helicase (EC 3.6.1.-), showing some
                     similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 PUTATIVE
                     ATP-DEPENDENT DNA HELICASE from Streptomyces coelicolor
                     (1159 aa), FASTA scores: opt: 666, E(): 1e-29, (34.5%
                     identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443 MISMATCH
                     REPAIR PROTEIN MUTU (DNA HELICASE II) from Pseudomonas
                     aeruginosa (728 aa), FASTA scores: opt: 239, E(): 7.3e-06,
                     (23.8% identity in 677 aa overlap) (no similarity in
                     C-terminal part for this one); etc. C-terminal region
                     similar to Q9FDU2|ORF3 ORF3 PROTEIN (FRAGMENT) from
                     Streptomyces griseus (551 aa), FASTA scores: opt: 800,
                     E(): 1.7e-37, (36.2% identity in 525 aa overlap); and
                     Q9ZG15 HYPOTHETICAL 35.5 KDA PROTEIN from Rhodococcus
                     erythropolis (323 aa), FASTA scores: opt: 232, E():
                     9.7e-06, (28.55% identity in 266 aa overlap). Mb3227c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y579"
                     /db_xref="InterPro:IPR000212"
                     /db_xref="InterPro:IPR013986"
                     /db_xref="InterPro:IPR014016"
                     /db_xref="InterPro:IPR014017"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR034739"
                     /db_xref="InterPro:IPR038726"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y579"
BEGIN
        1 MSHIWGVEAG AALAPGLRGP VLVLGGPGTG KSTLLVEAAV AHIGAGTDPE SVLLLTGSGR
       61 MGMRARSALT TALLRSRTNG PCRAAIREPV VRTVHSYAYA VLRKAAQRAG DALPRLLTSA
      121 EQDAIIRELL AGDAEDGPAA TTTWPAHLRP ALTTAGFATE LRNLLARCAE RGLDPLELQQ
      181 LGRRRGRPEW IAAGQFAQRY EQVMLLRGAV GLAAPQATAP ALSAAELVGA ALEAFAVDPE
      241 LLAAERARVR TLLVDDAQQL DPQAARLVRM LAAGTELALI AGDPNQAVFG FRGGEPTGLL
      301 ADDPPPAGGA PIPSVTLTVS HRCAPAVARA VTGIARRLPG RSVGRRIEGT GTEVGSVTVR
      361 LAGSAHAEAA MIADALRRAH LIDGVPWSQM AVIVRSVPRA VRLPRALAAA GVPVAPPAVG
      421 GPLSAEPAVR ALLTVLEATA DGLDGDQALL LLTGPIGGVD PVSLRQLRRT LQRARPGQTS
      481 RKFGDLLVEV LGGDAPPSGP GSRALRRVRA VLTAAARCHR SGSLGGQDPR HTLWAAWQRS
      541 GLQRRWLAAS EHGGAAAVQA TRDLETVTAL FDITDHYVSR TSGASLRGLV EHVTALQLPV
      601 VRPEPAAPTE QVMVLSAHAA LGHEWDLVVI AGLQDGLWPN TVPRGGVLGT QRLLDELDGV
      661 TKDASMRAPL LAEERRLLVT AMGRARRRLL VTAVDSDAGG GGHEAVLPSA FFFEIAQWAD
      721 GDGEPVAMQP VSAPRVLSAA AVVGRLRAVV CAPACAVDDA DRDCAATQLA RLAKAGVPGA
      781 DPSEWHGLAP VSTSDPLCDS DDLVTLTPST LQALNDCPLR WLAERHGGTN TRELPSAVGS
      841 VLHALFAEPG RSESQLLAEL DRVWGHLPFG AQWYSANELA RHRAMIQAFV QWRAQSRSEL
      901 TEVGVEVDID GALEDGSGQA RKIRLRGRAD RLERDPAGRL VIVDIKTGKT PVSKDDAQQH
      961 AQLAMYQLAV AEGLVRAGDE PGGARLVYVG KSGAAGVAER KQDPLTPAAR DEWRNLVRQL
     1021 AAATAGPQFI ARRNDGCTHC PLRPGCPAHV RGSAP
//