LOCUS       SIU01853.1               355 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            TRANSMEMBRANE CATION TRANSPORTER protein.
ACCESSION   LT708304-3267
PROTEIN_ID  SIU01853.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3225C"
                     /note="Mb3225c, -, len: 355 aa. Equivalent to Rv3200c,
                     len: 355 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 355 aa overlap). Possible transmembrane
                     cation transporter, similar to many transmembrane proteins
                     and putative potassium channels e.g. Q9XA52|SCGD3.27C
                     PUTATIVE MEMBRANE PROTEIN from Streptomyces coelicolor
                     (365 aa), FASTA scores: opt: 1022, E(): 2.6e-53, (49.85%
                     identity in 325 aa overlap); Q9RRZ3|DR2336 PUTATIVE
                     POTASSIUM CHANNEL from Deinococcus radiodurans (320 aa),
                     FASTA scores: opt: 436, E(): 1e-18, (30.9% identity in 304
                     aa overlap); O28600|AF1673 PUTATIVE POTASSIUM CHANNEL from
                     Archaeoglobus fulgidus (314 aa), FASTA scores: opt: 363,
                     E(): 2.1e-14, (27.2% identity in 309 aa overlap);
                     Q57604|Y13B_METJAMJ0138.1|MJ0138.1 PUTATIVE POTASSIUM
                     CHANNEL from Methanococcus jannaschii (333 aa), FASTA
                     scores: opt: 356, E(): 5.7e-14, (26.0% identity in 281 aa
                     overlap); P73132|SLL0993 POTASSIUM CHANNEL from
                     Synechocystis sp. strain PCC 6803 (365 aa), FASTA scores:
                     opt: 330, E(): 2.1e-12, (27.8% identity in 324 aa
                     overlap); etc. Contains PS00017 ATP/GTP-binding site motif
                     A (P-loop). Protein product from Mb3225c detected using
                     shotgun mass spectrometry. Mb3225c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3F6"
                     /db_xref="InterPro:IPR003148"
                     /db_xref="InterPro:IPR013099"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3F6"
BEGIN
        1 MAGSWRRLRG LDEKLTAQPG YALVGVLRIP QRRASPARVI SRRVVVAVVA LLLTAGIVYV
       61 DRDGYLDAQG DRLTFLDCLY YAAVTLSTTG YGDITPISEF ARAINIFVIT PLRIAFLILL
      121 VGTTLEVLTE TSRQAYKIQR WRSRVRNHTV VIGYGTKGKT AVAAMVSDEL VPGEIVVVDT
      181 DSGVLERAAA AGLVTVHGDA TKSDVLRLAG TQHASSIIVA TSRDDTAVLV TLTAREIAPK
      241 AKIVASIREA ENQHLLRQSG ADTVVVSSET AGRLLGIATT TPSVVEMIED LLTPEAGLAV
      301 AEREVEQAEV GGSPRHLRDI VLGVVRDGQL LRIGAPEVDA IEASDRLLYI RQVGR
//