LOCUS SIU01848.1 447 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER protein. ACCESSION LT708304-3262 PROTEIN_ID SIU01848.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3220" /note="Mb3220, -, len: 447 aa. Equivalent to Rv3197, len: 447 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 447 aa overlap). Probable conserved ATP-binding protein ABC transporter, highly similar to Mycobacterium leprae proteins: Q9CCM8|ML0640 HYPOTHETICAL PROTEIN (473 aa), FASTA scores: opt: 2512, E(): 2.1e-140, (83.0% identity in 447 aa overlap). Interestingly, the N-terminal half (1-219 aa) corresponds to Q49747|ABC1|B1937_C3_233 ABC1 PROTEIN from Mycobacterium leprae (267 aa), FASTA scores: opt: 1276, E(): 6.3e-68, (88.6% identity in 219 aa overlap); and the C-terminal half (239-447 aa) corresponds to Q49745|B1937_C2_179 HYPOTHETICAL 23.1 KDA PROTEIN (206 aa), FASTA scores: opt: 1138, E(): 6.5e-60, (77.05% identity in 209 aa overlap); two adjacent orfs from Mycobacterium leprae. Also highly similar to other proteins (generally ABC transporters) e.g. Q9FCJ6|2SC3B6.16c HYPOTHETICAL 51.3 KDA PROTEIN from Streptomyces coelicolor (469 aa), FASTA scores: opt: 1340, E(): 1.8e-71, (45.9% identity in 449 aa overlap); O65576|ABC1AT ABC1 PROTEIN (alias Q9SBB2|T15B16.14|AT4G01660 PUTATIVE ABC TRANSPORTER) from Arabidopsis thaliana (Mouse-ear cress) (623 aa), FASTA scores: opt: 543, E(): 1.7e-24, (28.4% identity in 405 aa overlap); O27682|MTH1645 ABC TRANSPORTER from Methanobacterium thermoautotrophicum (623 aa), FASTA scores: opt: 497, E(): 7.8e-22, (33.0% identity in 309 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS). Protein product from Mb3220 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3220 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y3R3" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR004147" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR034646" /db_xref="UniProtKB/TrEMBL:A0A1R3Y3R3" BEGIN 1 MDDGSVSDIK RGRAARNAKL ASIPVGFAGR AALGLGKRLT GKSKDEVTAE LMEKAANQLF 61 TVLGELKGGA MKVGQALSVM EAAIPDEFGE PYREALTKLQ KDAPPLPASK VHRVLDGQLG 121 TKWRERFSSF NDTPVASASI GQVHKAIWSD GREVAVKIQY PGADEALRAD LKTMQRMVGV 181 LKQLSPGADV QGVVDELVER TEMELDYRLE AANQRAFAKA YHDHPRFQVP HVVASAPKVV 241 IQEWIEGVPM AEIIRHGTTE QRDLIGTLLA ELTFDAPRRL GLMHGDAHPG NFMLLPDGRM 301 GIIDFGAVAP MPGGFPIELG MTIRLAREKN YDLLLPTMEK AGLIQRGRQV SVREIDEMLR 361 QYVEPIQVEV FHYTRKWLQK MTVSQIDRSV AQIRTARQMD LPAKLAIPMR VIASVGAILC 421 QLDAHVPIKA LSEELIPGFA EPDAIVV //