LOCUS       SIU01848.1               447 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED ATP-BINDING PROTEIN ABC TRANSPORTER protein.
ACCESSION   LT708304-3262
PROTEIN_ID  SIU01848.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3220"
                     /note="Mb3220, -, len: 447 aa. Equivalent to Rv3197, len:
                     447 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 447 aa overlap). Probable conserved
                     ATP-binding protein ABC transporter, highly similar to
                     Mycobacterium leprae proteins: Q9CCM8|ML0640 HYPOTHETICAL
                     PROTEIN (473 aa), FASTA scores: opt: 2512, E(): 2.1e-140,
                     (83.0% identity in 447 aa overlap). Interestingly, the
                     N-terminal half (1-219 aa) corresponds to
                     Q49747|ABC1|B1937_C3_233 ABC1 PROTEIN from Mycobacterium
                     leprae (267 aa), FASTA scores: opt: 1276, E(): 6.3e-68,
                     (88.6% identity in 219 aa overlap); and the C-terminal
                     half (239-447 aa) corresponds to Q49745|B1937_C2_179
                     HYPOTHETICAL 23.1 KDA PROTEIN (206 aa), FASTA scores: opt:
                     1138, E(): 6.5e-60, (77.05% identity in 209 aa overlap);
                     two adjacent orfs from Mycobacterium leprae. Also highly
                     similar to other proteins (generally ABC transporters)
                     e.g. Q9FCJ6|2SC3B6.16c HYPOTHETICAL 51.3 KDA PROTEIN from
                     Streptomyces coelicolor (469 aa), FASTA scores: opt: 1340,
                     E(): 1.8e-71, (45.9% identity in 449 aa overlap);
                     O65576|ABC1AT ABC1 PROTEIN (alias
                     Q9SBB2|T15B16.14|AT4G01660 PUTATIVE ABC TRANSPORTER) from
                     Arabidopsis thaliana (Mouse-ear cress) (623 aa), FASTA
                     scores: opt: 543, E(): 1.7e-24, (28.4% identity in 405 aa
                     overlap); O27682|MTH1645 ABC TRANSPORTER from
                     Methanobacterium thermoautotrophicum (623 aa), FASTA
                     scores: opt: 497, E(): 7.8e-22, (33.0% identity in 309 aa
                     overlap); etc. Contains PS00017 ATP/GTP-binding site motif
                     A (P-loop). BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN
                     FAMILY (ABC TRANSPORTERS). Protein product from Mb3220
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3220 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3R3"
                     /db_xref="InterPro:IPR002575"
                     /db_xref="InterPro:IPR004147"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR034646"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3R3"
BEGIN
        1 MDDGSVSDIK RGRAARNAKL ASIPVGFAGR AALGLGKRLT GKSKDEVTAE LMEKAANQLF
       61 TVLGELKGGA MKVGQALSVM EAAIPDEFGE PYREALTKLQ KDAPPLPASK VHRVLDGQLG
      121 TKWRERFSSF NDTPVASASI GQVHKAIWSD GREVAVKIQY PGADEALRAD LKTMQRMVGV
      181 LKQLSPGADV QGVVDELVER TEMELDYRLE AANQRAFAKA YHDHPRFQVP HVVASAPKVV
      241 IQEWIEGVPM AEIIRHGTTE QRDLIGTLLA ELTFDAPRRL GLMHGDAHPG NFMLLPDGRM
      301 GIIDFGAVAP MPGGFPIELG MTIRLAREKN YDLLLPTMEK AGLIQRGRQV SVREIDEMLR
      361 QYVEPIQVEV FHYTRKWLQK MTVSQIDRSV AQIRTARQMD LPAKLAIPMR VIASVGAILC
      421 QLDAHVPIKA LSEELIPGFA EPDAIVV
//