LOCUS       SIU01844.1               340 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            CONSERVED SECRETED PROTEIN protein.
ACCESSION   LT708304-3258
PROTEIN_ID  SIU01844.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3216C"
                     /note="Mb3216c, -, len: 340 aa. Equivalent to Rv3194c,
                     len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 340 aa overlap). Possible conserved
                     secreted protein (N-terminal stretch hydrophobic),
                     equivalent to Q9CCM7|ML0643 PUTATIVE SECRETED PROTEIN from
                     Mycobacterium leprae (340 aa), FASTA scores: opt: 1822,
                     E(): 1.6e-102, (80.3% identity in 340 aa overlap). Also
                     similar to other proteins e.g. Q9FCI6|2SC3B6.26 PUTATIVE
                     SECRETED PROTEIN from Streptomyces coelicolor (364 aa),
                     FASTA scores: opt: 430, E(): 1.1e-18, (40.95% identity in
                     359 aa overlap); Q9S3Y5|SDRC SDRC PROTEIN from
                     Streptomyces coelicolor (241 aa), FASTA scores: opt: 396,
                     E(): 8.9e-17, (35.2% identity in 318 aa overlap)
                     (similarity in part for this one); O34470|YLBL YLBL
                     PROTEIN from Bacillus subtilis (350 aa), FASTA scores:
                     opt: 385, E(): 5.6e-16, (27.7% identity in 350 aa
                     overlap); etc. Protein product from Mb3216c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb3216c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3D6"
                     /db_xref="InterPro:IPR001478"
                     /db_xref="InterPro:IPR008269"
                     /db_xref="InterPro:IPR014721"
                     /db_xref="InterPro:IPR020568"
                     /db_xref="InterPro:IPR027065"
                     /db_xref="InterPro:IPR036034"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3D6"
BEGIN
        1 MNRRILTLMV ALVPIVVFGV LLAVVTVPFV ALGPGPTFDT LGEIDGKQVV QIVGTQTYPT
       61 SGHLNMTTVS QRDGLTLGEA LALWLSGQEQ LMPRDLVYPP GKSREEIEND NAADFKRSEA
      121 AAEYAALGYL KYPKAVTVAS VMDPGPSVDK LQAGDAIDAV DGTPVGNLDQ FTALLKNTKP
      181 GQEVTIDFRR KNEPPGIAQI TLGKNKDRDQ GVLGIEVVDA PWAPFAVDFH LANVGGPSAG
      241 LMFSLAVVDK LTSGHLVGST FVAGTGTIAV DGKVGQIGGI THKMAAARAA GATVFLVPAK
      301 NCYEASSDSP PGLKLVKVET LSQAVDALHA MTSGSPTPSC
//