LOCUS       SIU01823.1               299 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            NON-HEME HALOPEROXIDASE HPX protein.
ACCESSION   LT708304-3237
PROTEIN_ID  SIU01823.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hpx"
                     /locus_tag="BQ2027_MB3196C"
                     /note="Mb3196c, hpx, len: 299 aa. Equivalent to Rv3171c,
                     len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 299 aa overlap). Possible hpx, non-heme
                     haloperoxidase (EC 1.11.1.-), similar to other hydrolases
                     (principaly epoxide hydrolases) and non-heme
                     chloroperoxidases e.g. Q9RKB6|SCE87.22c PUTATIVE HYDROLASE
                     from Streptomyces coelicolor (314 aa), FASTA scores: opt:
                     431, E(): 6e-20, (38.05% identity in 297 aa overlap);
                     Q9HZ14|PA3226 PROBABLE HYDROLASE (SIMILAR TO ALPHA/BETA
                     HYDROLASE FOLD) from Pseudomonas aeruginosa (275 aa),
                     FASTA scores: opt: 236, E(): 1e-07, (29.6% identity in 277
                     aa overlap); Q9DBL9|1300003 D03RIK PROTEIN SIMILAR TO
                     ALPHA/BETA HYDROLASE FOLD from Mus musculus (Mouse) (351
                     aa), FASTA scores: opt: 223, E(): 8.3e-07, (24.35%
                     identity in 304 aa overlap); AAK46260|MT1988 EPOXIDE
                     HYDROLASE from Mycobacterium tuberculosis strain CDC1551
                     (356 aa), FASTA scores: opt: 223, E(): 8.4e-07, (40.7%
                     identity in 113 aa overlap); P49323|PRXC_STRLI|CPO|CPOL
                     NON-HEME CHLOROPEROXIDASE (EC 1.11.1.10) (CHLORIDE
                     PEROXIDASE) from Streptomyces lividans (275 aa), FASTA
                     scores: opt: 220, E(): 1e-06, (29.5% identity in 305 aa
                     overlap); etc. Equivalent to AAK47599 Hydrolase,
                     alpha/beta hydrolase family from Mycobacterium
                     tuberculosis strain CDC1551 but shorter 24 aa. Start
                     chosen by similarity, alternative with good RBS possible.
                     Protein product from Mb3196c detected using SWATH mass
                     spectrometry. Mb3196c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3B7"
                     /db_xref="InterPro:IPR022742"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3B7"
BEGIN
        1 MTVRAADGTP LHTQVFGPPH GYPIVLTHGF VCAIRAWAYQ IADLAGDYRV IAFDHRGHGR
       61 SGVPRRGAYS LNHLAADLDS VLDATLAPRE RAVVAGHSMG GITIAAWSDR YRHKVRRRTD
      121 AVALINTTTG DLVRKVKLLS VPRELSPVRV LAGRSLVNTF GGFPLPGAAR ALSRHVISTL
      181 AVAADADPSA TRLVYELFTQ MSAAGRGGCA KMLVEEVGSA HLNLDGLTVP TLVIGGVRDR
      241 LTPISQSRRI ARTAPNVVGL VELPGGHCSM LERHQEVNSH LRALAESVTR HVRDRRISS
//