LOCUS       SIU01822.1               448 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE OXIDASE)
            (MAO) protein.
ACCESSION   LT708304-3236
PROTEIN_ID  SIU01822.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="aofH"
                     /locus_tag="BQ2027_MB3195"
                     /note="Mb3195, aofH, len: 448 aa. Equivalent to Rv3170,
                     len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 448 aa overlap). Probable aofH,
                     flavin-containing (mono)amine oxidase (EC 1.4.3.4),
                     similar to many eukaryotic monoamine oxidases e.g.
                     P49253|AOF_ONCMY from Oncorhynchus mykiss (Rainbow trout)
                     (Salmo gairdneri) (522 aa), FASTA scores: opt: 869, E():
                     5.3e-44, (37.7% identity in 448 aa overlap);
                     P21396|AOFA_RAT|MAOA from Rattus norvegicus (Rat) (526
                     aa), FASTA scores: opt: 839, E(): 3.2e-42, (37.45%
                     identity in 446 aa overlap); Q99NA8|MAO-A from Cavia
                     porcellus (Guinea pig) (506 aa), FASTA scores: opt: 836,
                     E(): 4.6e-42, (37.0% identity in 446 aa overlap);
                     P21398|AOFA_BOVIN from Bos taurus (Bovine) (527 aa), FASTA
                     scores: opt: 806, E(): 2.8e-40, (37.0% identity in 446 aa
                     overlap); P21397|AOFA_HUMAN (527 aa), FASTA scores: opt:
                     801, E(): 5.6e-40, (37.2% identity in 446 aa overlap);
                     etc. Alternative start possible at position 3538487.
                     BELONGS TO THE FLAVIN MONOAMINE OXIDASE FAMILY. COFACTOR:
                     FAD (POTENTIAL). Protein product from Mb3195 detected
                     using SWATH mass spectrometry. Mb3195 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P63534"
                     /db_xref="InterPro:IPR001613"
                     /db_xref="InterPro:IPR002937"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="UniProtKB/Swiss-Prot:P63534"
BEGIN
        1 MTNPPWTVDV VVVGAGFAGL AAARELTRQG HEVLVFEGRD RVGGRSLTGR VAGVPADMGG
       61 SFIGPTQDAV LALATELGIP TTPTHRDGRN VIQWRGSARS YRGTIPKLSL TGLIDIGRLR
      121 WQFERIARGV PVAAPWDARR ARELDDVSLG EWLRLVRATS SSRNLMAIMT RVTWGCEPDD
      181 VSMLHAARYV RAAGGLDRLL DVKNGAQQDR VPGGTQQIAQ AAAAQLGARV LLNAAVRRID
      241 RHGAGVTVTS DQGQAEAGFV IVAIPPAHRV AIEFDPPLPP EYQQLAHHWP QGRLSKAYAA
      301 YSTPFWRASG YSGQALSDEA PVFITFDVSP HADGPGILMG FVDARGFDSL PIEERRRDAL
      361 RCFASLFGDE ALDPLDYVDY RWGTEEFAPG GPTAAVPPGS WTKYGHWLRE PVGPIHWAST
      421 ETADEWTGYF DGAVRSGQRA AAEVAALL
//