LOCUS       SIU01808.1               553 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            NADH DEHYDROGENASE I (CHAIN M) NUOK (NADH-UBIQUINONE OXIDOREDUCTASE 
            CHAIN M) protein.
ACCESSION   LT708304-3222
PROTEIN_ID  SIU01808.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="nuoM"
                     /locus_tag="BQ2027_MB3181"
                     /note="Mb3181, nuoM, len: 553 aa. Equivalent to Rv3157,
                     len: 553 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 553 aa overlap). Probable nuoM,
                     integral membrane NADH dehydrogenase I, chain M (EC
                     1.6.5.3), similar to others e.g. Q9XAR6|NUOM from
                     Streptomyces coelicolor (523 aa), FASTA scores: opt: 1621,
                     E(): 4.2e-89, (56.55% identity in 541 aa overlap);
                     P50974|NUOM_RHOCA|NUOM from Rhodobacter capsulatus
                     (Rhodopseudomonas capsulata) (512 aa), FASTA scores: opt:
                     996, E(): 6.5e-52, (38.2% identity in 521 aa overlap);
                     P29925|NQOD_PARDE|NQO13 from Paracoccus denitrificans (513
                     aa), FASTA scores: opt: 987, E(): 2.2e-51, (37.05%
                     identity in 540 aa overlap); etc. Also similar to
                     MTCY251.04 (FASTA score: E(): 3.3e-16) and MTCY03A2.02c
                     (FASTA score: E(): 9.6e-13). SIMILAR TO POLYPEPTIDE 4 OF
                     THE NADH-UBIQUINOL OXIDOREDUCTASE OF CHLOROPLASTS OR
                     MITOCHONDRIAL. Protein product from Mb3181 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb3181 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3M4"
                     /db_xref="InterPro:IPR001750"
                     /db_xref="InterPro:IPR003918"
                     /db_xref="InterPro:IPR010227"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3M4"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MNNVPWLSVL WLVPLAGAVL IILLPPGRRR LAKWAGMVVS VLTLAVSIVV AAEFKPSAEP
       61 YQFVEKHSWI PAFGAGYTLG VDGIAVVLVL LTTVLIPLLL VAGWNDATDA DDLSPASGRY
      121 PQRPAPPRLR SSGGERTRGV HAYVALTLAI ESMVLMSVIA LDVLLFYVFF EAMLIPMYFL
      181 IGGFGQGAGR SRAAVKFLLY NLFGGLIMLA AVIGLYVVTA QYDSGTFDFR EIVAGVAAGR
      241 YGADPAVFKA LFLGFMFAFA IKAPLWPFHR WLPDAAVEST PATAVLMMAV MDKVGTFGML
      301 RYCLQLFPDP STYFRPLIVT LAIIGVIYGA IVAIGQTDMM RLIAYTSISH FGFIIAGIFV
      361 MTTQGQSGST LYMLNHGLST AAVFLIAGFL IARRDSRSIA DYGGVQKVAP ILAGTFMVSA
      421 MATVSLPGLA PFISEFLVLL GTFSRYWLAA AFGVTALVLS AVYMLWLYQR VMTGPIAEGN
      481 ERIGDLVGRE MIVVAPLIAL LLVLGVYPKP VLDIINPAVE NTMTTIGQHD PAPSVAHPVP
      541 AVGASRTAEG PHP
//