LOCUS       SIU01804.1               211 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            NADH DEHYDROGENASE I (CHAIN I) NUOI (NADH-UBIQUINONE OXIDOREDUCTASE 
            CHAIN I) protein.
ACCESSION   LT708304-3218
PROTEIN_ID  SIU01804.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="nuoI"
                     /locus_tag="BQ2027_MB3177"
                     /note="Mb3177, nuoI, len: 211 aa. Equivalent to Rv3153,
                     len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 211 aa overlap). Probable nuoI, NADH
                     dehydrogenase I, chain I (EC 1.6.5.3), similar to others
                     e.g. Q9XAR2|NUOI from Streptomyces coelicolor (211 aa),
                     FASTA scores: opt: 825, E(): 9.3e-44, (70.1% identity in
                     164 aa overlap); Q56224|NQO9_THETH from Thermus aquaticus
                     (subsp. thermophilus) (182 aa), FASTA scores: opt: 543,
                     E(): 1.8e-26, (50.9% identity in 163 aa overlap);
                     Q9RU95|DR1497 from Deinococcus radiodurans (178 aa), FASTA
                     scores: opt: 527, E(): 1.7e-25, (48.75% identity in 162 aa
                     overlap); etc. Contains two 4Fe-4S ferredoxins,
                     iron-sulfur binding region signatures (PS00198). BELONGS
                     TO THE COMPLEX I 23 KDA SUBUNIT FAMILY. THE IRON-SULFUR
                     CENTERS ARE SIMILAR TO THOSE OF 'BACTERIAL-TYPE' 4FE-4S
                     FERREDOXINS. COFACTOR: BINDS TWO 4FE-4S CLUSTERS. Protein
                     product from Mb3177 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3177 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:Q7TX57"
                     /db_xref="InterPro:IPR010226"
                     /db_xref="InterPro:IPR017896"
                     /db_xref="InterPro:IPR017900"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TX57"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MANTDRPALP HKRAVPPSRA DSGPRRRRTK LLDAVAGFGV TLGSMFKKTV TEEYPERPGP
       61 VAARYHGRHQ LNRYPDGLEK CIGCELCAWA CPADAIYVEG ADNTEEERFS PGERYGRVYQ
      121 INYLRCIGCG LCIEACPTRA LTMTYDYELA DDNRADLIYE KDRLLAPLLP EMAAPPHPRA
      181 PGATDKDYYL GNVTAEGLRG VRESQTTGDS R
//