LOCUS       SIU01799.1               440 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            NADH DEHYDROGENASE I (CHAIN D) NUOD (NADH-UBIQUINONE OXIDOREDUCTASE 
            CHAIN D) protein.
ACCESSION   LT708304-3213
PROTEIN_ID  SIU01799.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="nuoD"
                     /locus_tag="BQ2027_MB3172"
                     /note="Mb3172, nuoD, len: 440 aa. Equivalent to Rv3148,
                     len: 440 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 440 aa overlap). Probable nuoD, NADH
                     dehydrogenase, chain B (EC 1.6.5.3), similar to others
                     e.g. Q9XAQ7|NUOD from Streptomyces coelicolor (440 aa),
                     FASTA scores: opt: 2198, E(): 1e-131, (73.9% identity in
                     429 aa overlap); P15689|NUCM_PARTE from Paramecium
                     tetraurelia (400 aa), FASTA scores: opt: 922, E():
                     5.8e-51, (38.5% identity in 408 aa overlap);
                     Q9RU89|NUOD_DEIRA|DR1503 from Deinococcus radiodurans (401
                     aa), FASTA scores: opt: 922, E(): 5.8e-51, (47.75%
                     identity in 404 aa overlap); etc. Equivalent to AAK47575
                     from Mycobacterium tuberculosis strain CDC1551 but longer
                     42 aa. Contains helix-turn-helix motif at aa 340-361.
                     BELONGS TO THE COMPLEX I 49 KDA SUBUNIT FAMILY. Protein
                     product from Mb3172 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3172 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P65570"
                     /db_xref="InterPro:IPR001135"
                     /db_xref="InterPro:IPR014029"
                     /db_xref="InterPro:IPR022885"
                     /db_xref="InterPro:IPR029014"
                     /db_xref="InterPro:IPR038290"
                     /db_xref="UniProtKB/Swiss-Prot:P65570"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTAIADSAGG AGETVLVAGG QDWQQVVDAA RSADPGERIV VNMGPQHPST HGVLRLILEI
       61 EGETVVEARC GIGYLHTGIE KNLEYRYWTQ GVTFVTRMDY LSPFFNETAY CLGVEKLLGI
      121 TDEIPERVNV IRVLMMELNR ISSHLVALAT GGMELGAMTP MFVGFRAREI VLTLFEKITG
      181 LRMNSAYIRP GGVAQDLPPN AATEIAEALK QLRQPLREMG ELLNENAIWK ARTQGVGYLD
      241 LTGCMALGIT GPILRSTGLP HDLRKSEPYC GYQHYEFDVI TDDSCDAYGR YMIRVKEMWE
      301 SMKIVEQCLD KLRPGPTMIS DRKLAWPADL QVGPDGLGNS PKHIAKIMGS SMEALIHHFK
      361 LVTEGIRVPA GQVYVAVESP RGELGVHMVS DGGTRPYRVH YRDPSFTNLQ SVAAMCEGGM
      421 VADLIAAVAS IDPVMGGVDR
//