LOCUS SIU01785.1 381 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 ppe family protein ppe50 protein. ACCESSION LT708304-3199 PROTEIN_ID SIU01785.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="PPE50" /locus_tag="BQ2027_MB3159" /note="Mb3159, PPE50, len: 381 aa. Similar to 5' end of Rv3135, len: 132 aa, from Mycobacterium tuberculosis strain H37Rv, (88.5% identity in 131 aa overlap). Member of the Mycobacterium tuberculosis Ala-, Gly-rich PPE family, similar to P95190|Rv3136|MTCY03A2.22c (380 aa), FASTA scores: opt: 494, E(): 6.7e-25, (57.25% identity in 131 aa overlap) (next ORF downstream), MTY21C12_9, MTCY3C7_24, MTCI125_27, MTV049_12, MTV049_9, MTV049_11, MTCY274_24 etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large 1337 bp insertion leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis strain H37Rv (381 aa versus 132 aa). Protein product from Mb3159 detected using SWATH mass spectrometry. Mb3159 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR000030" /db_xref="InterPro:IPR022171" /db_xref="InterPro:IPR038332" /db_xref="UniProtKB/TrEMBL:A0A1R3Y534" BEGIN 1 MDYAFLPPEI NSARMYSGPG PNSMLVAAAS WDALAAELAS AAENYGSVIA RLTGMHWWGP 61 ASTSMLAMSA PYVEWLERTA AQTKQTATQA RAAAAAFEQA HAMTVPPALV TANRAELKAL 121 IASNLLGQNT AAIAAIEAQY AEMWAQDAAA MYGYATTSAA ARQLTPFSSP QQTTNPAGLA 181 AQNAAVTQAA TNSAGNTPTA LSQLSSFLSQ AVEAPTGWPN ILPDDFTILD GILAAYATVG 241 VTQDIESICA GIIGAENNLG LLGAASENPA ELAPGAFGID AALSSAEKGA AASMHDAVLA 301 SAGRAGSIGP MSVPPSWATP SSTPVSALSG AGLTTLDGTD VAEHGTPGLP GVPAGTDKRA 361 SGVIPRYGVR LTVMSRPPAA G //