LOCUS       SIU01783.1               217 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 TWO
            COMPONENT TRANSCRIPTIONAL REGULATORY PROTEIN DEVR (PROBABLY
            LUXR/UHPA-FAMILY) protein.
ACCESSION   LT708304-3197
PROTEIN_ID  SIU01783.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="devR"
                     /locus_tag="BQ2027_MB3157C"
                     /note="Mb3157c, devR, len: 217 aa. Equivalent to Rv3133c,
                     len: 217 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 217 aa overlap). devR, two component
                     transcriptional regulator (see first citation below; dev
                     for Differentially Expressed in Virulent strain), highly
                     similar to several e.g. O85372|CPRR TWO COMPONENT
                     REGULATOR from Rhodococcus sp. (212 aa), FASTA scores:
                     opt: 868, E(): 6.2e-46, (65.05% identity in 206 aa
                     overlap); Q9RI42|SCJ12.16c PUTATIVE LUXR FAMILY
                     TWO-COMPONENT RESPONSE REGULATOR from Streptomyces
                     coelicolor (233 aa), FASTA scores: opt: 849, E(): 9.7e-45,
                     (60.55% identity in 218 aa overlap); Q9XA59|SCGD3.19
                     PUTATIVE TWO-COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL
                     REGULATOR from Streptomyces coelicolor (218 aa), FASTA
                     scores: opt: 835, E(): 6.5e-44, (61.55% identity in 208 aa
                     overlap); and similar to others. Contains bacterial
                     regulatory proteins, LuxR family signature (PS00622) near
                     C-terminus as seen in bvgA, comA, dctR, degU, evgA, fimZ,
                     fixJ, gacA, glpR, narL, narP, nodW, rcsB and uhpA.
                     Helix-turn-helix motif at 166-187 (+3.15 SD). BELONGS TO
                     THE LUXR/UHPA FAMILY OF TRANSCRIPTIONAL REGULATORS. THE
                     N-TERMINAL REGION IS SIMILAR TO THAT OF OTHER REGULATORY
                     COMPONENTS OF SENSORY TRANSDUCTION SYSTEMS. Protein
                     product from Mb3157c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3157c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y377"
                     /db_xref="InterPro:IPR000792"
                     /db_xref="InterPro:IPR001789"
                     /db_xref="InterPro:IPR011006"
                     /db_xref="InterPro:IPR016032"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y377"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MVKVFLVDDH EVVRRGLVDL LGADPELDVV GEAGSVAEAM ARVPAARPDV AVLDVRLPDG
       61 NGIELCRDLL SRMPDLRCLI LTSYTSDEAM LDAILAGASG YVVKDIKGME LARAVKDVGA
      121 GRSLLDNRAA AALMAKLRGA AEKQDPLSGL TDQERTLLGL LSEGLTNKQI ADRMFLAEKT
      181 VKNYVSRLLA KLGMERRTQA AVFATELKRS RPPGDGP
//