LOCUS       SIU01782.1               578 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 TWO
            COMPONENT SENSOR HISTIDINE KINASE DEVS protein.
ACCESSION   LT708304-3196
PROTEIN_ID  SIU01782.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="devS"
                     /locus_tag="BQ2027_MB3156C"
                     /note="Mb3156c, devS, len: 578 aa. Equivalent to Rv3132c,
                     len: 578 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 578 aa overlap). devS, membrane-bound
                     two component sensor histidine kinase (EC 2.7.3.-) (see
                     citations below; dev for Differentially Expressed in
                     Virulent strain), similar to others two component sensors
                     e.g. Q9RI43|SCJ12.15c PUTATIVE TWO-COMPONENT SENSOR from
                     Streptomyces coelicolor (585 aa), FASTA scores: opt: 1305,
                     E(): 2.5e-69, (41.35% identity in 573 aa overlap);
                     Q9ZBY4|SCD78.15 PUTATIVE TWO COMPONENT SENSOR from
                     Streptomyces coelicolor (560 aa), FASTA scores: opt: 1194,
                     E(): 8.1e-63, (41.05% identity in 558 aa overlap);
                     O85371|CPRS TWO COMPONENT REGULATOR from Rhodococcus sp
                     (563 aa), FASTA scores: opt: 803, E(): 8.3e-40, (38.4%
                     identity in 552 aa overlap); Q9L094|SCC24.23 PUTATIVE
                     TWO-COMPONENT SENSOR HISTIDINE KINASE from Streptomyces
                     coelicolor (similarity only in C-terminus for this one);
                     etc. Also highly similar to mycobacterium
                     O53473|Rv2027c|MTV018.14c PUTATIVE MEMBRANE PROTEIN (573
                     aa), FASTA scores: opt: 2333, E(): 7.6e-130, (61.45%
                     identity in 576 aa overlap). Protein product from Mb3156c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb3156c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y364"
                     /db_xref="InterPro:IPR003018"
                     /db_xref="InterPro:IPR003594"
                     /db_xref="InterPro:IPR005467"
                     /db_xref="InterPro:IPR011712"
                     /db_xref="InterPro:IPR029016"
                     /db_xref="InterPro:IPR036890"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y364"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTTGGLVDEN DGAAMRPLRH TLSQLRLHEL LVEVQDRVEQ IVEGRDRLDG LVEAMLVVTA
       61 GLDLEATLRA IVHSATSLVD ARYGAMEVHD RQHRVLHFVY EGIDEETVRR IGHLPKGLGV
      121 IGLLIEDPKP LRLDDVSAHP ASIGFPPYHP PMRTFLGVPV RVRDESFGTL YLTDKTNGQP
      181 FSDDDEVLVQ ALAAAAGIAV ANARLYQQAK ARQSWIEATR DIATELLSGT EPATVFRLVA
      241 AEALKLTAAD AALVAVPVDE DMPAADVGEL LVIETVGSAV ASTVGRTIPV AGAVLREVFV
      301 NGIPRRVDRV DLEGLDELAD AGPALLLPLR ARGTVAGVVV VLSQGGPGAF TDEQLEMMAA
      361 FADQAALAWQ LATSQRRMRE LDVLTDRDRI ARDLHDHVIQ RLFAIGLALQ GAVPHERNPE
      421 VQQRLSDVVD DLQDVIQEIR TTIYDLHGAS QGITRLRQRI DAAVAQFADS GLRTSVQFVG
      481 PLSVVDSALA DQAEAVVREA VSNAVRHAKA STLTVRVKVD DDLCIEVTDN GRGLPDEFTG
      541 SGLTNLRQRA EQAGGEFTLA SVPGASGTVL RWSAPLSQ
//