LOCUS SIU01760.1 527 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE AGPS (ALKYL-DHAP SYNTHASE) (ALKYLGLYCERONE-PHOSPHATE SYNTHASE) protein. ACCESSION LT708304-3174 PROTEIN_ID SIU01760.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="agpS" /locus_tag="BQ2027_MB3134C" /note="Mb3134c, agpS, len: 527 aa. Equivalent to Rv3107c, len: 527 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 527 aa overlap). Possible agpS, alkyl-dihydroxyacetonephosphate synthase (EC 2.5.1.26), similar to others and some various enzymes e.g. AAK46595|MT2311 PUTATIVE ALKYL-DIHYDROXYACETONEPHOSPHATE SYNTHASE from Mycobacterium tuberculosis strain CDC1551 (529 aa), FASTA scores: opt: 1052, E(): 2.1e-58, (37.1% identity in 542 aa overlap); Q9RJ97|SCF91.28c PUTATIVE FLAVOPROTEIN from Streptomyces coelicolor (530 aa), FASTA scores: opt: 972, E(): 2.2e-53, (36.2% identity in 544 aa overlap); O96759|ADAS_DICDI ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE (EC 2.5.1.26) from Dictyostelium discoideum (Slime mold) (611 aa), FASTA scores: opt: 617, E(): 4.5e-31, (33.95% identity in 480 aa overlap); O97157|ADAS_TRYBB ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE from Trypanosoma brucei (613 aa), FASTA scores: opt: 567, E(): 6.2e-28, (29.15% identity in 521 aa overlap); etc. Also similar to O53525|Rv2251|MTV022.01 HYPOTHETICAL 49.8 KDA PROTEIN from Mycobacterium tuberculosis strain H37Rv (475 aa), FASTA scores: opt: 1019, E(): 2.3e-56, (38.6% identity in 487 aa overlap). BELONGS TO THE FAD-BINDING OXIDOREDUCTASE/TRANSFERASE FAMILY 4. COFACTOR: FAD (BY SIMILARITY). Protein product from Mb3134c detected using SWATH mass spectrometry. Mb3134c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y363" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR036318" /db_xref="UniProtKB/TrEMBL:A0A1R3Y363" BEGIN 1 MRSWWGWGTV EDALSDQETQ ALQSRVAALV SGHDLSDHPP PDLTALGLAA PRVSPPASLA 61 ALCSSDLVDR AGHARGKAYR DIARNLQGQL DHLPDLIARP RSEQDVIDVL DWCAREGIAV 121 IPYGGGSSVV GGVEPRFDEP VVTVDVTAMS AVLEIDRVSR AARIQAGAFG PSIEHQLRPH 181 DLTLRHFPQS FGFSTLGGWL ATRSGGHFAT LYTHIDDLTE SLRIVTPVGI SESRRLPGSG 241 AGPSPDRLFL GSEGTLGIIT EAWMRLQHRP RWQVTVSVVF DDWAAAVAAT RTIAQAGLYP 301 ANCRLLDPAE ALLNAGTSVG GGLLVLAFES ADHPIDPWLH RAVAITAEHG GTVTAQRSRG 361 TTSDATEHNA AANWRSAFLR MPYQRDALVR RGVIAETFET ACTWDGFDTL HAAVTDAART 421 AIWKVCGTGV VTCRFTHVYP DGPAPYYGIY AGGRWGSLDA QWDEIKAAVS EAISASGGTI 481 THHHAVGRDH RAWYDRQRPD PFAAALRAAK SALDPAGILN PGVLLGR //