LOCUS       SIU01747.1               158 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 HYPOTHETICAL
            TRANSCRIPTIONAL REGULATORY PROTEIN protein.
ACCESSION   LT708304-3161
PROTEIN_ID  SIU01747.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3122"
                     /note="Mb3122, -, len: 158 aa. Equivalent to Rv3095, len:
                     158 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 158 aa overlap). Possible regulatory
                     protein, because contains possible helix-turn-helix motif
                     at aa 39-61 (+4.83 SD). Similar to hypothetical proteins
                     e.g. Q9I0C9|PA2713 from Pseudomonas aeruginosa (159 aa),
                     FASTA scores: opt: 486, E(): 1.6e-25, (45.95% identity in
                     148 aa overlap); Q9AAF6|CC0645 from Caulobacter crescentus
                     (188 aa), FASTA scores: opt: 479, E(): 5.3e-25, (45.75%
                     identity in 153 aa overlap); Q9K408|2SCG61.07 from
                     Streptomyces coelicolor (157 aa), FASTA scores: opt: 407,
                     E(): 2.8e-20, (43.9% identity in 139 aa overlap); etc.
                     Protein product from Mb3122 detected using SWATH mass
                     spectrometry. Mb3122 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A649"
                     /db_xref="InterPro:IPR002577"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="UniProtKB/Swiss-Prot:P0A649"
BEGIN
        1 MAVSDLSHRF EGESVGRALE LVGERWTLLI LREAFFGVRR FGQLARNLGI PRPTLSSRLR
       61 MLVEVGLFDR VPYSSDPERH EYRLTEAGRD LFAAIVVLMQ WGDEYLPRPE GPPIKLRHHT
      121 CGEHADPRLI CTHCGEEITA RNVTPEPGPG FKAKLASS
//