LOCUS SIU01747.1 158 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 HYPOTHETICAL TRANSCRIPTIONAL REGULATORY PROTEIN protein. ACCESSION LT708304-3161 PROTEIN_ID SIU01747.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3122" /note="Mb3122, -, len: 158 aa. Equivalent to Rv3095, len: 158 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 158 aa overlap). Possible regulatory protein, because contains possible helix-turn-helix motif at aa 39-61 (+4.83 SD). Similar to hypothetical proteins e.g. Q9I0C9|PA2713 from Pseudomonas aeruginosa (159 aa), FASTA scores: opt: 486, E(): 1.6e-25, (45.95% identity in 148 aa overlap); Q9AAF6|CC0645 from Caulobacter crescentus (188 aa), FASTA scores: opt: 479, E(): 5.3e-25, (45.75% identity in 153 aa overlap); Q9K408|2SCG61.07 from Streptomyces coelicolor (157 aa), FASTA scores: opt: 407, E(): 2.8e-20, (43.9% identity in 139 aa overlap); etc. Protein product from Mb3122 detected using SWATH mass spectrometry. Mb3122 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P0A649" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:P0A649" BEGIN 1 MAVSDLSHRF EGESVGRALE LVGERWTLLI LREAFFGVRR FGQLARNLGI PRPTLSSRLR 61 MLVEVGLFDR VPYSSDPERH EYRLTEAGRD LFAAIVVLMQ WGDEYLPRPE GPPIKLRHHT 121 CGEHADPRLI CTHCGEEITA RNVTPEPGPG FKAKLASS //