LOCUS       SIU01738.1               368 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ZINC-TYPE ALCOHOL DEHYDROGENASE ADHD (ALDEHYDE REDUCTASE)
            protein.
ACCESSION   LT708304-3152
PROTEIN_ID  SIU01738.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="adhD"
                     /locus_tag="BQ2027_MB3113"
                     /note="Mb3113, adhD, len: 368 aa. Equivalent to Rv3086,
                     len: 368 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 368 aa overlap). Probable adhD,
                     zinc-type alcohol dehydrogenase (EC 1.1.1.-), highly
                     similar to many e.g. O69045 HYPOTHETICAL ALCOHOL
                     DEHYDROGENASE from Rhodococcus rhodochrous (370 aa), FASTA
                     scores: opt: 1255, E(): 8.7e-68, (50.4% identity in 367 aa
                     overlap); P25406|ADHB_UROHA ALCOHOL DEHYDROGENASE I-B from
                     Uromastyx hardwickii (Indian spiny-tailed lizard) (375
                     aa), FASTA scores: opt: 787, E(): 8.2e-40, (35.9% identity
                     in 373 aa overlap); P72324||ADHI_RHOSH ALCOHOL
                     DEHYDROGENASE CLASS III from Rhodobacter sphaeroides
                     (Rhodopseudomonas sphaeroides) (376 aa), FASTA scores:
                     opt: 787, E(): 8.3e-40, (35.1% identity in 379 aa
                     overlap). Also highly similar to
                     P71818|Rv0761c|MTCY369.06c HYPOTHETICAL ZINC-TYPE ALCOHOL
                     DEHYDROGENASE-LIKE PROTEIN from Mycobacterium tuberculosis
                     strain H37Rv (375 aa), FASTA scores: opt: 1186, E():
                     1.2e-63, (47.3% identity in 368 aa overlap). Contains
                     PS00059 Zinc-containing alcohol dehydrogenases signature.
                     BELONGS TO THE ZINC-CONTAINING ALCOHOL DEHYDROGENASE.
                     POSSIBLY REQUIRES ZINC FOR ITS ACTIVITY. Protein product
                     from Mb3113 detected using SWATH mass spectrometry. Mb3113
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y3F2"
                     /db_xref="InterPro:IPR002328"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR020843"
                     /db_xref="InterPro:IPR023921"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y3F2"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MKTTAAVLFE AGKPFELMEL DLDGPGPGEV LVKYTAAGLC HSDLHLTDGD LPPRFPIVGG
       61 HEGSGVIEEV GAGVTRVKPG DHVVCSFIPN CGTCRYCCTG RQNLCDMGAT ILEGCMPDGS
      121 FRFHSQGTDF GAMCMLGTFA ERATVSQHSV VKVDDWLPLE TAVLVGCGVP SGWGTAVNAG
      181 NLRAGDTAVI YGVGGLGINA VQGATAAGCK YVVVVDPVAF KRETALKFGA THAFADAASA
      241 AAKVDELTWG QGADAALILV GTVDDEVVSA ATAVIGKGGT VVITGLADPA KLTVHVSGTD
      301 LTLHEKTIKG SLFGSCNPQY DIVRLLRLYD AGQLMLDELV TTTYNLEQVN QGYQDLRDGK
      361 NIRGVIVH
//