LOCUS SIU01734.1 340 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 VIRULENCE-
REGULATING TRANSCRIPTIONAL REGULATOR VIRS (ARAC/XYLS FAMILY)
protein.
ACCESSION LT708304-3148
PROTEIN_ID SIU01734.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="virS"
/locus_tag="BQ2027_MB3109C"
/note="Mb3109c, virS, len: 340 aa. Equivalent to Rv3082c,
len: 340 aa, from Mycobacterium tuberculosis strain H37Rv,
(99.7% identity in 340 aa overlap). virS, transcriptional
regulatory protein araC/xylS family, probably involved in
virulence (see citation below). Similar to many
transcriptional regulators araC/xylS family e.g.
Q9HZ25|PA3215 PROBABLE TRANSCRIPTIONAL REGULATOR
(ARAC/XYLS FAMILY) from Pseudomonas aeruginosa (337 aa),
FASTA scores: opt: 379, E(): 3e-17, (30.4% identity in 306
aa overlap); Q9Z3Y6|PHBR POLYHYDROXYBUTYRATE
TRANSCRIPTIONAL ACTIVATOR from Pseudomonas sp. 61-3 (379
aa), FASTA scores: opt: 336, E(): 2e-14, (26.35% identity
in 334 aa overlap); P72171|ORUR|PA0831 ORNITHINE
UTILIZATION TRANSCRIPTIONAL REGULATOR oruR from
Pseudomonas aeruginosa (339 aa), FASTA scores: opt: 274,
E(): 1.9e-10, (23.7% identity in 321 aa overlap); Q9ZFW7
VIRULENCE REGULATING HOMOLOG from Pseudomonas alcaligenes
(346 aa), FASTA scores: opt: 262, E(): 1.2e-09, (24.5%
identity in 339 aa overlap); etc. Also similar to
O69703|Rv3736|MTV025.084 PUTATIVE REGULATORY PROTEIN
(ARAC/XYLS FAMILY) from Mycobacterium tuberculosis strain
H37Rv (353 aa), FASTA scores: opt: 656, E(): 3.5e-35,
(36.95% identity in 333 aa overlap). Has potential
helix-turn-helix motif at positions 252-273. BELONGS TO
THE ARAC/XYLS FAMILY OF TRANSCRIPTIONAL REGULATORS.
Protein product from Mb3109c detected using SWATH mass
spectrometry. Mb3109c found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:A0A1R3Y337"
/db_xref="InterPro:IPR009057"
/db_xref="InterPro:IPR018060"
/db_xref="InterPro:IPR032687"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y337"
BEGIN
1 MELGSLIRAT NLWGYTDLMR ELGADPLPFL RRFDIPPGIE HQEDAFMSLA GFVRMLEASA
61 AELDCPDFGL RLARWQGLGI LGPVAVIARN AATLFGGLEA IGRYLYVHSP ALTLTVSSTT
121 ARSNVRFGYE VTEPGIPYPL QGYELSMANA ARMIRLLGGP QARARVFSFR HAQLGTDAAY
181 REALGCTVRF GRTWCGFEVD HRLAGRPIDH ADPETKRIAT KYLESQYLPS DATLSERVVG
241 LARRLLPTGQ CSAEAIADQL DMHPRTLQRR LAAEGLRCHD LIERERRAQA ARYLAQPGLY
301 LSQIAVLLGY SEQSALNRSC RCWFGMTPRQ YRAYGGVSGR
//