LOCUS       SIU01727.1               307 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Similar
            to citrate lyase beta chain, 3 protein.
ACCESSION   LT708304-3141
PROTEIN_ID  SIU01727.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3102C"
                     /note="Mb3102c, -, len: 307 aa. Equivalent to Rv3075c,
                     len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 307 aa overlap). Conserved
                     hypopthetical protein, with some similarity to
                     Q9I562|PA0883 PROBABLE ACYL-COA LYASE BETA CHAIN from
                     Pseudomonas aeruginosa (275 aa), FASTA scores: opt: 408,
                     E(): 9.2e-19, (35.15% identity in 273 aa overlap);
                     Q9S2U9|SC4G6.02 PUTATIVE CITRATE LYASE BETA CHAIN from
                     Streptomyces coelicolor (274 aa), FASTA scores: opt: 384,
                     E(): 3.1e-17, (34.7% identity in 265 aa overlap);
                     O06162|CITE|Rv2498c|MTCY07A7.04c from Mycobacterium
                     tuberculosis (273 aa), FASTA scores: opt: 349, E():
                     5.1e-15, (35.2% identity in 264 aa overlap); etc. Several
                     initiation codons possible, first one chosen. Protein
                     product from Mb3102c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3102c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y375"
                     /db_xref="InterPro:IPR005000"
                     /db_xref="InterPro:IPR011206"
                     /db_xref="InterPro:IPR015813"
                     /db_xref="InterPro:IPR040442"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y375"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTSMYEQVDT NTADPVAGSR IDPVLARSWL LVNGAHGDRF ESAAHSRADI VVLDIEDAVA
       61 PKDKHAARDN AVRWFGDGNA DWVRINGFGT PWWADDLAML ADSPVGGVML AMVESVDHVT
      121 ETAKRLPNVP IVALVETARG LERINEIAAA KGTFRLAFGI GDFRRDTGFG EDPATLAYAR
      181 SRFTIAARAA GLPSAIDGPT IGSNALKLIE ATAVSAEFGM TGKICLSPDQ CPVVNEGLSP
      241 SQDEIVWAKE FFAEFARDGG EIRNGSDLPR IARATKILDL ARAYGIEVSD FEDEPVHMPA
      301 PTDTYHY
//