LOCUS SIU01720.1 547 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
PHOSPHOGLUCOMUTASE PGMA (GLUCOSE PHOSPHOMUTASE) (PGM)
protein.
ACCESSION LT708304-3134
PROTEIN_ID SIU01720.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="pgmA"
/locus_tag="BQ2027_MB3095C"
/note="Mb3095c, pgmA, len: 547 aa. Equivalent to Rv3068c,
len: 547 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 547 aa overlap). Probable pgmA,
phosphoglucomutase (EC 5.4.2.2), highly similar to other
phosphoglucomutases e.g. Q9L117|PGM from Streptomyces
coelicolor (546 aa), FASTA scores: opt: 2569, E():
2.8e-149, (71.4% identity in 545 aa overlap);
Q9ABY5|CC0085 from Caulobacter crescentus (545 aa), FASTA
scores: opt: 2465, E(): 6.2e-143, (70.4% identity in 541
aa overlap); P38569|PGMU_ACEXY|CELB from Acetobacter
xylinum (555 aa), FASTA scores: opt: 2206, E(): 4e-127,
(62.25% identity in 543 aa overlap); P74643|PGM|SLL0726
from Synechocystis sp. strain PCC 6803 (567 aa), FASTA
scores: opt: 2168, E(): 8.5e-125, (60.0% identity in 550
aa overlap); P36938|PGMU_ECOLI|PGM|B0688 from Escherichia
coli (546 aa), FASTA scores: opt: 2111, E(): 2.5e-121,
(58.2% identity in 550 aa overlap). Also similar to other
phosphomannomutases. Has phosphoglucomutase and
phosphomannomutase signature (PS00710) and ATP/GTP-binding
site motif A (P-loop) (PS00017). BELONGS TO THE
PHOSPHOHEXOSE MUTASES FAMILY. Protein product from Mb3095c
detected using shotgun mass spectrometry and SWATH mass
spectrometry. Mb3095c found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:A0A1R3Y324"
/db_xref="InterPro:IPR005843"
/db_xref="InterPro:IPR005844"
/db_xref="InterPro:IPR005845"
/db_xref="InterPro:IPR005846"
/db_xref="InterPro:IPR005852"
/db_xref="InterPro:IPR016055"
/db_xref="InterPro:IPR016066"
/db_xref="InterPro:IPR036900"
/db_xref="UniProtKB/TrEMBL:A0A1R3Y324"
BEGIN
1 MVANPRAGQP AQPEDLVDLP HLVTAYYSIE PDPDDLAQQV AFGTSGHRGS ALTGTFNELH
61 ILAITQAIVE YRAAQGTTGP LFIGRDTHGL SEPAWVSALE VLAANQVVAV VDSRDRYTPT
121 PAISHAILTY NRGRTEALAD GIVVTPSHNP PSDGGIKYNP PNGGPADTAA TTAIAKRANE
181 ILLARSMVKR LPLARALRTA QRHDYLGHYV DDLPNVVDIA AIREAGVRIG ADPLGGASVD
241 YWGEIAHRHG LDLTVVNPLV DATWRFMTLD TDGKIRMDCS SPDAMAGLIR TMFGNRERYQ
301 IATGNDADAD RHGIVTPDEG LLNPNHYLAV AIEYLYTHRP SWPAGIAVGK TVVSSSIIDR
361 VVAGIGRQLV EVPVGFKWFV DGLIGATLGF GGEESAGASF LRRDGSVWTT DKDGIIMALL
421 AAEILAVTGA TPSQRYHALA GEYGGPCYAR IDAPADREQK ARLARLSADQ VSATELAGEP
481 ITAKLTTAPG NGAALGGLKV TTANAWFAAR PSGTEDVYKI YAESFRGPQH LVEVQQTARE
541 VVDRVIG
//