LOCUS       SIU01712.1               600 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ACYL-COA DEHYDROGENASE FADE22b [SECOND PART] protein.
ACCESSION   LT708304-3126
PROTEIN_ID  SIU01712.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadE22b"
                     /locus_tag="BQ2027_MB3087C"
                     /note="Mb3087c, fadE22b, len: 600 aa. Equivalent to 3' end
                     of Rv3061c, len: 721 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100.0% identity in 600 aa overlap).
                     Probable fadE22, Acyl-CoA Dehydrogenase (EC 1.3.99.-),
                     similar to many e.g. AAK44503|MT0284 from Mycobacterium
                     tuberculosis strain CDC1551 (731 aa), FASTA scores: opt:
                     1804, E(): 1.1e-101, (43.45% identity in 743 aa overlap);
                     AAK48037|MT3678 from Mycobacterium tuberculosis strain
                     CDC1551 (711 aa), FASTA scores: opt: 1630, E(): 3.9e-91,
                     (42.55% identity in 733 aa overlap); and extensive
                     similarity in C-terminal part to many acyl-CoA
                     dehydrogenases e.g. Q9A5G9|CC2478 from Caulobacter
                     crescentus (407 aa), FASTA scores: opt: 767, E(): 4.8e-39,
                     (36.7% identity in 376 aa overlap). Also similar to many
                     hypothetical proteins. COULD BELONG TO THE ACYL-COA
                     DEHYDROGENASES FAMILY. REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium tuberculosis strain H37Rv, fadE22 exists as
                     a single gene. In Mycobacterium bovis, a frameshift due to
                     a single base insertion (*-c) splits fadE22 into 2 parts,
                     fadE22a and fadE22b. Protein product from Mb3087c detected
                     using SWATH mass spectrometry. Mb3087c found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2Z8"
                     /db_xref="InterPro:IPR006091"
                     /db_xref="InterPro:IPR009075"
                     /db_xref="InterPro:IPR009100"
                     /db_xref="InterPro:IPR013786"
                     /db_xref="InterPro:IPR036250"
                     /db_xref="InterPro:IPR037069"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2Z8"
BEGIN
        1 MGLDSQVQVT DGVADGEAGI VLGAGLAELL LVAAGDDVLV LERGRKGVSV DVPENFDPTR
       61 RSGRVRLDNV RVTTDDILLG AYESALARAR TLLAAEAVGG AADCVDSAVA YAKVRQQFGR
      121 TIATFQAVKH HCANMLVAAE SAIAAVWDAA RAAAEDEEQF RLAAAVAAAL AFPAYARNAE
      181 LNIQVHGGIG FTWEHDAHLH LRRALVTVGL FGGDAPVRDV FERTAAGVTR AISLDLPAQA
      241 EELRARIRSD AAEIAALEKD AQRDKLIETG YVMPHWPRPW GRAAGAVEQL VIEEEFSAAG
      301 IERPDYSITG WVILTLIQHG TPWQIERFVE KALRQQEIWC QLFSEPDAGS DAASVKTRAT
      361 RVEGGWKING QKVWTSGAQY CARGLATVRT DPDAPKHAGI TTVIIDMLAP GVEVRPLRQI
      421 TGDSEFNEVF FNDVFVPDED VVGAPNSGWT VARATLGNER VSIGGSGSYY EAMAAKLVQL
      481 VQRRSDAFAG APIRVGAFLA EDHALRLLNL RRAARSVEGA GPGPEGNITK LKVAEHMIEG
      541 AAIAAALWGP EIALLDGPGR VIGRTVMGAR GMAIAGGTSE VTRNQIAERI LGMPRDPLIS
//