LOCUS       SIU01711.1               490 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY)
            protein.
ACCESSION   LT708304-3125
PROTEIN_ID  SIU01711.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3086C"
                     /note="Mb3086c, -, len: 490 aa. Equivalent to Rv3060c,
                     len: 490 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 490 aa overlap). Probable
                     transcriptional regulatory protein, showing reasonable
                     similarity to several members of the GntR family e.g.
                     BAB54431|MLL8575 from Rhizobium loti (Mesorhizobium loti)
                     (247 aa), FASTA scores: opt: 274, E(): 3.5e-10, (30.35%
                     identity in 224 aa overlap); P96570|ESMR from Burkholderia
                     cepacia (Pseudomonas cepacia) (277 aa), FASTA scores: opt:
                     229, E(): 2.8e-07, (25.85% identity in 240 aa overlap);
                     Q9S276|SCI28.07 from Streptomyces coelicolor (230 aa),
                     FASTA scores: opt: 211, E(): 3.4e-06, (27.25% identity in
                     220 aa overlap); etc. Seems to have two domains: residues
                     1-260 resemble UxuR, and 260-490 resemble PdhR, ExuR, etc.
                     Contains bacterial regulatory proteins, GntR family
                     signature (PS00043). Helix-turn-helix motif (+3.13 SD) at
                     aa 38-59. SEEMS TO BELONG TO THE GNTR FAMILY OF
                     TRANSCRIPTIONAL REGULATORS. Mb3086c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y304"
                     /db_xref="InterPro:IPR000524"
                     /db_xref="InterPro:IPR008920"
                     /db_xref="InterPro:IPR011711"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y304"
BEGIN
        1 MSTEPDAVWT DKRASKIARR IEADIVRRGW PIGASLGSES ALQQRFCVSR SVLREAVRLV
       61 EHHQVARMRR GPNGGLFICE PNAGPATRAV VIYLEYLGTT IGDLLGARLV LEPLAASLAA
      121 EHIDEPGIER LRAVLRAEER WRPGLPPPPE QFYRVLAEQS KNPVLQLFID ILMRLTKRYV
      181 QKSGTQSAGE AVEAAGQVHN EHSDIVAAVT AGDSAWAKTL SERHVEAVAG WLQQHQRGND
      241 AAVRNGGRAR EPRRAQQLIL GAPRGKLAEV LAATIGDDIA ASGWQVGSVF GTETALLERY
      301 QVSRAVLREA VRLLEYHAIA HMRRGPGGGL VVTTPQPQAS IDTIALYLQY RKPSREDLRC
      361 VRDAIEIDNV AKVVKRRSEP EVASFLDTLG RPRLDNPTDD VRAAAVEEFR FHVGLARAAG
      421 NTMLDLFLLI LVELFRRHLS STEQALPTWS DVVAVGHAHV RILEAIGSGD DSLARCRTRR
      481 HLDAAASWWL
//