LOCUS SIU01711.1 490 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY GNTR-FAMILY) protein. ACCESSION LT708304-3125 PROTEIN_ID SIU01711.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3086C" /note="Mb3086c, -, len: 490 aa. Equivalent to Rv3060c, len: 490 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 490 aa overlap). Probable transcriptional regulatory protein, showing reasonable similarity to several members of the GntR family e.g. BAB54431|MLL8575 from Rhizobium loti (Mesorhizobium loti) (247 aa), FASTA scores: opt: 274, E(): 3.5e-10, (30.35% identity in 224 aa overlap); P96570|ESMR from Burkholderia cepacia (Pseudomonas cepacia) (277 aa), FASTA scores: opt: 229, E(): 2.8e-07, (25.85% identity in 240 aa overlap); Q9S276|SCI28.07 from Streptomyces coelicolor (230 aa), FASTA scores: opt: 211, E(): 3.4e-06, (27.25% identity in 220 aa overlap); etc. Seems to have two domains: residues 1-260 resemble UxuR, and 260-490 resemble PdhR, ExuR, etc. Contains bacterial regulatory proteins, GntR family signature (PS00043). Helix-turn-helix motif (+3.13 SD) at aa 38-59. SEEMS TO BELONG TO THE GNTR FAMILY OF TRANSCRIPTIONAL REGULATORS. Mb3086c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y304" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/TrEMBL:A0A1R3Y304" BEGIN 1 MSTEPDAVWT DKRASKIARR IEADIVRRGW PIGASLGSES ALQQRFCVSR SVLREAVRLV 61 EHHQVARMRR GPNGGLFICE PNAGPATRAV VIYLEYLGTT IGDLLGARLV LEPLAASLAA 121 EHIDEPGIER LRAVLRAEER WRPGLPPPPE QFYRVLAEQS KNPVLQLFID ILMRLTKRYV 181 QKSGTQSAGE AVEAAGQVHN EHSDIVAAVT AGDSAWAKTL SERHVEAVAG WLQQHQRGND 241 AAVRNGGRAR EPRRAQQLIL GAPRGKLAEV LAATIGDDIA ASGWQVGSVF GTETALLERY 301 QVSRAVLREA VRLLEYHAIA HMRRGPGGGL VVTTPQPQAS IDTIALYLQY RKPSREDLRC 361 VRDAIEIDNV AKVVKRRSEP EVASFLDTLG RPRLDNPTDD VRAAAVEEFR FHVGLARAAG 421 NTMLDLFLLI LVELFRRHLS STEQALPTWS DVVAVGHAHV RILEAIGSGD DSLARCRTRR 481 HLDAAASWWL //