LOCUS       SIU01710.1               492 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CYTOCHROME P450 136 CYP136 protein.
ACCESSION   LT708304-3124
PROTEIN_ID  SIU01710.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cyp136"
                     /locus_tag="BQ2027_MB3085"
                     /note="Mb3085, cyp136, len: 492 aa. Equivalent to Rv3059,
                     len: 492 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 492 aa overlap). Probable cyp136,
                     cytochrome P450 136 (EC 1.14.-.-), similar to other
                     cytochrome P450-dependent oxidases e.g.
                     Q59990|CYP120|CYP|SLR0574 PUTATIVE CYTOCHROME P450 120
                     from Synechocystis sp. strain PCC 6803 (444 aa), FASTA
                     scores: opt: 579, E(): 1.5e-29, (27.3% identity in 443 aa
                     overlap); Q64654|CYP51|CP51_RAT CYTOCHROME P450 51 (EC
                     1.14.14.-) (LANOSTEROL 14-ALPHA DEMETHYLASE) from Rattus
                     norvegicus (Rat) (503 aa), FASTA scores: opt: 549, E():
                     1.4e-27, (26.2% identity in 458 aa overlap); Q9JIY3|CYP51
                     LANOSTEROL 14-ALPHA-DEMETHYLASE from Mus musculus (Mouse)
                     (486 aa), FASTA scores: opt: 546, E(): 2.1e-27, (25.75%
                     identity in 458 aa overlap). Contains cytochrome P450
                     cysteine heme-iron ligand signature (PS00086). BELONGS TO
                     THE CYTOCHROME P450 FAMILY. Protein product from Mb3085
                     detected using SWATH mass spectrometry. Mb3085 found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y314"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002403"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="InterPro:IPR036396"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y314"
BEGIN
        1 MATIHPPAYL LDQAKRRFTP SFNNFPGMSL VEHMLLNTKF PEKKLAEPPP GSGLKPVVGD
       61 AGLPILGHMI EMLRGGPDYL MFLYKTKGPV VFGDSAVLPG VAALGPDAAQ VIYSNRNKDY
      121 SQQGWVPVIG PFFHRGLMLL DFEEHMFHRR IMQEAFVRSR LAGYLEQMDR VVSRVVADDW
      181 VVNDARFLVY PAMKALTLDI ASMVFMGHEP GTDHELVTKV NKAFTITTRA GNAVIRTSVP
      241 PFTWWRGLRA RELLENYFTA RVKERREASG NDLLTVLCQT EDDDGNRFSD ADIVNHMIFL
      301 MMAAHDTSTS TATTMAYQLA AHPEWQQRCR DESDRHGDGP LDIESLEQLE SLDLVMNESI
      361 RLVTPVQWAM RQTVRDTELL GYYLPKGTNV IAYPGMNHRL PEIWTDPLTF DPERFTEPRN
      421 EHKRHRYAFT PFGGGVHKCI GMVFGQLEIK TILHRLLRRY RLELSRPDYQ PRWDYSAMPI
      481 PMDGMPIVLR PR
//