LOCUS SIU01701.1 246 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY ASNC-FAMILY) protein. ACCESSION LT708304-3115 PROTEIN_ID SIU01701.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB3076C" /note="Mb3076c, -, len: 246 aa. Equivalent to Rv3050c, len: 246 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 246 aa overlap). Probable transcriptional regulatory protein tetR-family, equivalent but shorter to Q9CBQ1|ML1733 from Mycobacterium leprae (275 aa), FASTA scores: opt: 1381,(E): 2.7e-79, (86.25% identity in 240 aa overlap); AAK44712|MT0489 from Mycobacterium tuberculosis strain CDC1551 (256 aa), FASTA scores: opt: 328,(E): 1.8e-13, (30.75% identity in 234 aa overlap); etc. Also some similarity to O53757|Rv0472c|MTV038.16c. Alternative starts possible at 68052 or 67923. Has potential helix-turn-helix motif at positons 51-72. Protein product from Mb3076c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb3076c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y2Z4" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="UniProtKB/TrEMBL:A0A1R3Y2Z4" BEGIN 1 MVRIPRPHPS AKPGVKVDAR SERWREHRKK VRNEIVDAAF RAIDRLGPEL SVRQIAEEAG 61 TAKPKIYRHF TDKSDLLEAI GMRLRDMLWA AIFPSLDLAT DSAREVIRRS VEEYVNLVDQ 121 HPNVLRVFIQ GRSAKQSEAT VRTLNEGREI TLAMAEMFNN ELREMELNRA ALELAAFAAF 181 GSAASATEWW LGPEPDSPRR MPREQFVAHL TTIMMGVIVG TAEALGIAVD PDQPIHDAVP 241 NNPAVR //