LOCUS       SIU01687.1               227 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED SECRETED PROTEIN TB22.2 protein.
ACCESSION   LT708304-3101
PROTEIN_ID  SIU01687.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="TB22.2"
                     /locus_tag="BQ2027_MB3062C"
                     /note="Mb3062c, TB22.2, len: 227 aa. Equivalent to
                     Rv3036c, len: 227 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.6% identity in 227 aa overlap). Probable
                     TB22.2, conserved secreted protein, with putative
                     N-terminal signal peptide, highly similar to secreted
                     immunogenic protein MPT64/MPB64 P19996|Rv1980c|MTCY39.39
                     from Mycobacterium tuberculosis and Mycobacterium bovis
                     (228 aa), FASTA scores: opt: 681, E(): 2.5e-35, (45.8%
                     identity in 227 aa overlap). Protein product from Mb3062c
                     detected using shotgun mass spectrometry. Mb3062c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="InterPro:IPR021729"
                     /db_xref="InterPro:IPR037126"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y336"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MRYLIATAVL VAVVLVGWPA AGAPPSCAGL GGTVQAGQIC HVHASGPKYM LDMTFPVDYP
       61 DQRALTDYIT QNRDGFVNVA QGSPLRDQPY QMDATSEQHS SGQPPQATRS VVLKFFQDLG
      121 GAHPSTWYKA FNYNLATSQP ITFDTLFVPG TTPLDSIYPI VQRELARQTG FGAAILPSTG
      181 LDPAHYQNFA ITDDSLIFYF AQGELLPSFV GACQAQVPRS AIPPLAI
//