LOCUS       SIU01667.1               437 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 ppe
            family protein ppe46 protein.
ACCESSION   LT708304-3081
PROTEIN_ID  SIU01667.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PPE46"
                     /locus_tag="BQ2027_MB3043C"
                     /note="Mb3043c, PPE46, len: 437 aa. Equivalent to Rv3018c,
                     len: 434 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 431 aa overlap). Member of PPE family
                     but lacks Gly, Ala rich repeats at C-terminal domain,
                     closest to MTCY261.19. Also very similar to following ORF
                     MTV012.35c. Nearly identical in parts to Mycobacterium
                     tuberculosis protein erroneously described as
                     DIHYDROFOLATE REDUCTASE (X59271|MTFOLA_1) P31500|DYR_MYCTU
                     (214 aa), FASTA scores: opt: 972, E(): 4.4e-42, (80.0%
                     identity in 195 aa overlap); and Z97559|MTCY261_19 from M.
                     tuberculosis cosmid (473 aa), FASTA scores: opt: 806, E():
                     0; (38.8% identity in 479 aa overlap); and
                     O53268|MTV012.35c from Mycobacterium tuberculosis (358
                     aa), FASTA scores: opt: 1714, E(): 3.3e-79, (78.3%
                     identity in 355 aa overlap).
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     56 bp deletion leads to a product slightly different at
                     the Nh2-terminus part compared to its homolog in
                     Mycobacterium tuberculosis strain H37Rv (434 aa versus 437
                     aa)."
                     /db_xref="GOA:A0A1R3Y315"
                     /db_xref="InterPro:IPR000030"
                     /db_xref="InterPro:IPR038332"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y315"
BEGIN
        1 MSSHRTPVWL ASPPEVHSAL LSAGPGPGSL QAAAAGWSAL SAEYAAVAQE LSAVVAAVGA
       61 GVWQGPSAEL FVAAYVPYVA WLVQASADSA AAAGEHEAAA AGYVCALAEM PTLPELAANH
      121 LTHAVLVATN FFGINTIPIA LNEADYVRMW VQAATVMSAY EAVVGAALVA TPHTGPAPVI
      181 VKPGANEASN AVAAATITPF PWHEIVQFLE ETFAAYDQYL SALLSELPAV AWVWFQLFVD
      241 ILGFNIIGFI ITLASNAQLL TEFAINASYV AVGLLYAIAG VIDIVVEWVI GNLFGVVPLL
      301 GGPLLGALAA AVVPGVAGLA GVAGLAAVPA VGAAAGAPAA LVGSVAPVSG GVVSPQARLV
      361 SAVEPAPAST SVSVLASDRG AGALGFVGTA GKESVGQPAG LTVLADEFGD GAPVPMLPGS
      421 WGPDLVGVAG DGGLVSV
//