LOCUS       SIU01652.1               618 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 acetolactate
            synthase (large subunit) ilvb1 (acetohydroxy-acid synthase)
            protein.
ACCESSION   LT708304-3066
PROTEIN_ID  SIU01652.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ilvB1"
                     /locus_tag="BQ2027_MB3028C"
                     /standard_name="ilvB"
                     /note="Mb3028c, ilvB1, len: 618 aa. Equivalent to Rv3003c,
                     len: 618 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 618 aa overlap). Probable ilvB1,
                     acetolactate synthase, large subunit (EC 4.1.3.18),
                     equivalent or highly similar to others e.g.
                     O33112|ILVB_MYCLE|MLCB637.20|ML1696 from Mycobacterium
                     leprae (625 aa), FASTA scores: opt: 3653, E(): 5.4e-208,
                     (87.1% identity in 627 aa overlap); Q59498|ILVB_MYCAV from
                     Mycobacterium avium (621 aa), FASTA scores: opt: 3473,
                     E(): 2.3e-197, (84.7% identity in 614 aa overlap);
                     P42463|ILVB_CORGL from Corynebacterium glutamicum
                     (Brevibacterium flavum) (626 aa), FASTA scores: opt: 2754,
                     E(): 5.9e-155, (65.8% identity in 589 aa overlap); etc.
                     Contains PS00187 Thiamine pyrophosphate enzymes signature.
                     COFACTOR: THIAMINE PYROPHOSPHATE, AND MAGNESIUM (BY
                     SIMILARITY). Note that previously known as ilvB. Protein
                     product from Mb3028c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3028c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P0A623"
                     /db_xref="InterPro:IPR000399"
                     /db_xref="InterPro:IPR011766"
                     /db_xref="InterPro:IPR012000"
                     /db_xref="InterPro:IPR012001"
                     /db_xref="InterPro:IPR012846"
                     /db_xref="InterPro:IPR029035"
                     /db_xref="InterPro:IPR029061"
                     /db_xref="InterPro:IPR039368"
                     /db_xref="UniProtKB/Swiss-Prot:P0A623"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSAPTKPHSP TFKPEPHSAA NEPKHPAARP KHVALQQLTG AQAVIRSLEE LGVDVIFGIP
       61 GGAVLPVYDP LFDSKKLRHV LVRHEQGAGH AASGYAHVTG RVGVCMATSG PGATNLVTPL
      121 ADAQMDSIPV VAITGQVGRG LIGTDAFQEA DISGITMPIT KHNFLVRSGD DIPRVLAEAF
      181 HIAASGRPGA VLVDIPKDVL QGQCTFSWPP RMELPGYKPN TKPHSRQVRE AAKLIAAARK
      241 PVLYVGGGVI RGEATEQLRE LAELTGIPVV TTLMARGAFP DSHRQNLGMP GMHGTVAAVA
      301 ALQRSDLLIA LGTRFDDRVT GKLDSFAPEA KVIHADIDPA EIGKNRHADV PIVGDVKAVI
      361 TELIAMLRHH HIPGTIEMAD WWAYLNGVRK TYPLSYGPQS DGSLSPEYVI EKLGEIAGPD
      421 AVFVAGVGQH QMWAAQFIRY EKPRSWLNSG GLGTMGFAIP AAMGAKIALP GTEVWAIDGD
      481 GCFQMTNQEL ATCAVEGIPV KVALINNGNL GMVRQWQSLF YAERYSQTDL ATHSHRIPDF
      541 VKLAEALGCV GLRCEREEDV VDVINQARAI NDCPVVIDFI VGADAQVWPM VAAGTSNDEI
      601 QAARGIRPLF DDITEGHA
//