LOCUS SIU01644.1 528 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) protein.
ACCESSION LT708304-3058
PROTEIN_ID SIU01644.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="serA1"
/locus_tag="BQ2027_MB3020C"
/standard_name="serA"
/note="Mb3020c, serA1, len: 528 aa. Equivalent to Rv2996c,
len: 528 aa, from Mycobacterium tuberculosis strain H37Rv,
(100.0% identity in 528 aa overlap). Probable serA1,
D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95),
equivalent to SERA_MYCLE D-3-PHOSPHOGLYCERATE
DEHYDROGENASE from Mycobacterium leprae (528 aa), FASTA
scores: opt: 2974, E(): 1.9e-166, (89.6% identity in 528
aa overlap). Also highly similar to many e.g. Q9Z564 from
Streptomyces coelicolor (529 aa), FASTA scores: opt: 1879,
E(): 2.1e-102, (57.6% identity in 526 aa overlap);
O29445|SERA_ARCFU from Archaeoglobus fulgidus (527 aa),
FASTA scores: opt: 1252, E(): 9.6e-66, (41.3% identity in
530 aa overlap); P35136|SERA_BACSU from Bacillus subtilis
(525 aa), FASTA scores: opt: 1172, E(): 4.5e-61, (37.9%
identity in 528 aa overlap); etc. Contains PS00017
ATP/GTP-binding site motif A (P-loop), PS00065 D-isomer
specific 2-hydroxyacid dehydrogenases NAD-binding
signature, and PS00670 D-isomer specific 2-hydroxyacid
dehydrogenases signature 2. BELONGS TO THE D-ISOMER
SPECIFIC 2-HYDROXYACID DEHYDROGENASES FAMILY. Note that
previously known as serA. Protein product from Mb3020c
detected using shotgun mass spectrometry and SWATH mass
spectrometry. Mb3020c found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:P0A545"
/db_xref="InterPro:IPR002912"
/db_xref="InterPro:IPR006139"
/db_xref="InterPro:IPR006140"
/db_xref="InterPro:IPR006236"
/db_xref="InterPro:IPR029009"
/db_xref="InterPro:IPR029752"
/db_xref="InterPro:IPR029753"
/db_xref="InterPro:IPR036291"
/db_xref="UniProtKB/Swiss-Prot:P0A545"
BEGIN
1 MSLPVVLIAD KLAPSTVAAL GDQVEVRWVD GPDRDKLLAA VPEADALLVR SATTVDAEVL
61 AAAPKLKIVA RAGVGLDNVD VDAATARGVL VVNAPTSNIH SAAEHALALL LAASRQIPAA
121 DASLREHTWK RSSFSGTEIF GKTVGVVGLG RIGQLVAQRI AAFGAYVVAY DPYVSPARAA
181 QLGIELLSLD DLLARADFIS VHLPKTPETA GLIDKEALAK TKPGVIIVNA ARGGLVDEAA
241 LADAITGGHV RAAGLDVFAT EPCTDSPLFE LAQVVVTPHL GASTAEAQDR AGTDVAESVR
301 LALAGEFVPD AVNVGGGVVN EEVAPWLDLV RKLGVLAGVL SDELPVSLSV QVRGELAAEE
361 VEVLRLSALR GLFSAVIEDA VTFVNAPALA AERGVTAEIC KASESPNHRS VVDVRAVGAD
421 GSVVTVSGTL YGPQLSQKIV QINGRHFDLR AQGINLIIHY VDRPGALGKI GTLLGTAGVN
481 IQAAQLSEDA EGPGATILLR LDQDVPDDVR TAIAAAVDAY KLEVVDLS
//