LOCUS       SIU01641.1               239 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            2-HYDROXYHEPTA-2,4-DIENE-1,7-DIOATE ISOMERASE (HHDD ISOMERASE)
            protein.
ACCESSION   LT708304-3055
PROTEIN_ID  SIU01641.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB3017C"
                     /note="Mb3017c, -, len: 239 aa. Equivalent to Rv2993c,
                     len: 239 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 239 aa overlap). Possible
                     2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (EC
                     5.3.3.-), equivalent to O33119|ML1689|MLCB637.28 POSSIBLE
                     2-HYDROXYHEPTA-2,4-DIENE- 1,7-DIOATE ISOMERASE from
                     Mycobacterium leprae (242 aa), FASTA scores: opt: 1427,
                     E(): 4.4e-86, (85.9% identity in 241 aa overlap). Also
                     similar to others e.g. Q9LBE3|DR1609 from Deinococcus
                     radiodurans (250 aa), FASTA scores: opt: 723, E():
                     5.5e-40, (49.05% identity in 216 aa overlap);
                     O27551|MTH1507 from Methanothermobacter thermautotrophicus
                     (260 aa), FASTA scores: opt: 708, E(): 5.4e-39, (52.1%
                     identity in 213 aa overlap); Q9HQR6|VNG1037G|HPCE from
                     Halobacterium sp. (strain NRC-1) (244 aa), FASTA scores:
                     opt: 590, E(): 2.7e-31, (43.65% identity in 220 aa
                     overlap); etc. Start chosen by homology, but ORF could
                     continue upstream. TBparse score is 0.896. Protein product
                     from Mb3017c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb3017c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2T1"
                     /db_xref="InterPro:IPR011234"
                     /db_xref="InterPro:IPR018833"
                     /db_xref="InterPro:IPR036663"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2T1"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTAREIAEHP FGTPTFTGRS WPLADVRLLA PILASKVVCV GKNYADHIAE MGGRPPADPV
       61 IFLKPNTAII GPNTPIRLPA NASPVHFEGE LAIVIGRACK DVPAAQAVDN ILGYTIGNDV
      121 SARDQQQSDG QWTRAKGHDT FCPVGPWIVT DLAPFDPADL ELRTVVNGDV KQHARTSLMI
      181 HDIGAIVEWI SAIMTLLPGD LILTGTPAGV GPIEDGDTVS ITIEGIGTLT NPVVRKGKP
//