LOCUS       SIU01632.1               742 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 polyphosphate
            kinase ppk (polyphosphoric acid kinase) (atp-polyphosphate
            phosphotransferase) protein.
ACCESSION   LT708304-3046
PROTEIN_ID  SIU01632.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ppk"
                     /locus_tag="BQ2027_MB3008"
                     /note="Mb3008, ppk, len: 742 aa. Equivalent to Rv2984,
                     len: 742 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 742 aa overlap). Probable ppk,
                     polyphosphate kinase (EC 2.7.4.1), equivalent to
                     O33127|PPK_MYCLE POLYPHOSPHATE KINASE from Mycobacterium
                     leprae (739 aa), FASTA scores: opt: 4264, E(): 0, (87.85%
                     identity in 742 aa overlap). Also highly similar to others
                     e.g. Q9KZV6|PPK_STRCO from Streptomyces coelicolor (746
                     aa), FASTA scores: opt: 1979, E(): 2.6e-117, (59.9%
                     identity in 701 aa overlap); Q9KD27|PPK_BACHD from
                     Bacillus halodurans (705 aa), FASTA scores: opt: 1319,
                     E(): 1.4e-75, (45.55% identity in 674 aa overlap);
                     Q9PAC7|PPK_XYLFA from Xylella fastidiosa (698 aa), FASTA
                     scores: opt: 1300, E(): 2.2e-74, (43.3% identity in 693 aa
                     overlap); etc. BELONGS TO THE POLYPHOSPHATE KINASE FAMILY.
                     Protein product from Mb3008 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3008 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P65769"
                     /db_xref="InterPro:IPR003414"
                     /db_xref="InterPro:IPR024953"
                     /db_xref="InterPro:IPR025198"
                     /db_xref="InterPro:IPR025200"
                     /db_xref="InterPro:IPR036830"
                     /db_xref="InterPro:IPR036832"
                     /db_xref="InterPro:IPR041108"
                     /db_xref="UniProtKB/Swiss-Prot:P65769"
BEGIN
        1 MMSNDRKVTE IENSPVTEVR PEEHAWYPDD SALAAPPAAT PAAISDQLPS DRYLNRELSW
       61 LDFNARVLAL AADKSMPLLE RAKFLAIFAS NLDEFYMVRV AGLKRRDEMG LSVRSADGLT
      121 PREQLGRIGE QTQQLASRHA RVFLDSVLPA LGEEGIYIVT WADLDQAERD RLSTYFNEQV
      181 FPVLTPLAVD PAHPFPFVSG LSLNLAVTVR QPEDGTQHFA RVKVPDNVDR FVELAAREAS
      241 EEAAGTEGRT ALRFLPMEEL IAAFLPVLFP GMEIVEHHAF RITRNADFEV EEDRDEDLLQ
      301 ALERELARRR FGSPVRLEIA DDMTESMLEL LLRELDVHPG DVIEVPGLLD LSSLWQIYAV
      361 DRPTLKDRTF VPATHPAFAE RETPKSIFAT LREGDVLVHH PYDSFSTSVQ RFIEQAAADP
      421 NVLAIKQTLY RTSGDSPIVR ALIDAAEAGK QVVALVEIKA RFDEQANIAW ARALEQAGVH
      481 VAYGLVGLKT HCKTALVVRR EGPTIRRYCH VGTGNYNSKT ARLYEDVGLL TAAPDIGADL
      541 TDLFNSLTGY SRKLSYRNLL VAPHGIRAGI IDRVEREVAA HRAEGAHNGK GRIRLKMNAL
      601 VDEQVIDALY RASRAGVRIE VVVRGICALR PGAQGISENI IVRSILGRFL EHSRILHFRA
      661 IDEFWIGSAD MMHRNLDRRV EVMAQVKNPR LTAQLDELFE SALDPCTRCW ELGPDGQWTA
      721 SPQEGHSVRD HQESLMERHR SP
//