LOCUS       SIU01625.1               333 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            THIAMINE-MONOPHOSPHATE KINASE THIL (THIAMINE-PHOSPHATE
            KINASE) protein.
ACCESSION   LT708304-3039
PROTEIN_ID  SIU01625.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="thiL"
                     /locus_tag="BQ2027_MB3001C"
                     /note="Mb3001c, thiL, len: 333 aa. Equivalent to Rv2977c,
                     len: 333 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 333 aa overlap). Possible thiL,
                     thiamin-monophosphate kinase (EC), equivalent to Q9CBS2
                     PROBABLE THIAMINE-MONOPHOSPHATE KINASE from Mycobacterium
                     leprae (325 aa), FASTA scores: opt: 1738, E(): 4.5e-98,
                     (80.9% identity in 314 aa overlap). Also highly similar to
                     others e.g. Q9ZBR7|SC7A1.06 PUTATIVE THIAMINE MONPHOSPHATE
                     KINASE from Streptomyces coelicolor (322 aa), FASTA
                     scores: opt: 959, E(): 7.8e-51, (51.1% identity in 319 aa
                     overlap); O05514|THIL_BACSU THIAMINE-MONOPHOSPHATE KINASE
                     from Bacillus subtilis (325 aa), FASTA scores: opt: 476,
                     E(): 1.5e-21, (35.15% identity in 273 aa overlap);
                     P77785|THIL_ECOLI|THIL|B0417 THIAMINE-MONOPHOSPHATE KINASE
                     from Escherichia coli strain K12 (325 aa), FASTA scores:
                     opt: 418, E(): 5e-18, (36.9% identity in 282 aa overlap);
                     etc. BELONGS TO THE THIAMINE-MONOPHOSPHATE KINASE FAMILY.
                     Note that the start, as given, is in IS1538. Protein
                     product from Mb3001c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb3001c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y4P8"
                     /db_xref="InterPro:IPR006283"
                     /db_xref="InterPro:IPR010918"
                     /db_xref="InterPro:IPR016188"
                     /db_xref="InterPro:IPR036676"
                     /db_xref="InterPro:IPR036921"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y4P8"
BEGIN
        1 MTTKDHSLAT ESPTLQQLGE FAVIDRLVRG RRQPATVLLG PGDDAALVSA GDGRTVVSTD
       61 MLVQDSHFRL DWSTPQDVGR KAIAQNAADI EAMGARATAF VVGFGAPAET PAAQASALVD
      121 GMWEEAGRIG AGIVGGDLVS CRQWVVSVTA IGDLDGRAPV LRSGAKAGSV LAVVGELGRS
      181 AAGYALWCNG IEDFAELRRR HLVPQPPYGH GAAAAAVGAQ AMIDVSDGLL ADLRHIAEAS
      241 GVRIDLSAAA LAADRDALTA AATALGTDPW PWVLSGGEDH ALVACFVGPV PAGWRTIGRV
      301 LDGPARVLVD GEEWTGYAGW QSFGEPDNQG SLG
//