LOCUS       SIU01603.1               275 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            GLYCOSYL TRANSFERASE protein.
ACCESSION   LT708304-3017
PROTEIN_ID  SIU01603.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2981"
                     /note="Mb2981, -, len: 275 aa. Equivalent to Rv2957, len:
                     275 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 275 aa overlap). Possible glycosyl
                     transferase (EC 2.4.1.-); possibly secreted protein.
                     Highly similar to O88109|GSD|GTFD GSD PROTEIN from
                     Mycobacterium avium subsp. silvaticum, Mycobacterium
                     paratuberculosis, and Mycobacterium avium (266 aa), FASTA
                     scores: opt: 1010, E(): 2.5e-62, (68.8% identity in 221 aa
                     overlap). Also some similarity with other proteins and
                     especially glycosyl transferases e.g. Q9AEE4 HYPOTHETICAL
                     31.4 KDA PROTEIN from Leptospira interrogans (265 aa),
                     FASTA scores: opt: 371, E(): 3.3e-18, (34.43% identity in
                     212 aa overlap); Q9EXY4 PUTATIVE GLYCOSYL TRANSFERASE from
                     Escherichia coli (248 aa), FASTA scores: opt: 339, E():
                     5e-16, (32.4% identity in 210 aa overlap); Q9RCC4
                     GLYCOSYLTRANSFERASE-LIKE PROTEIN from Yersinia pestis (247
                     aa), FASTA scores: opt: 333, E(): 1.3e-15, (31.8% identity
                     in 217 aa overlap); Q9EXY1 PUTATIVE GLYCOSYL TRANSFERASE
                     from Escherichia coli (248 aa), FASTA scores: opt: 328,
                     E(): 2.9e-15, (31.9% identity in 210 aa overlap); etc.
                     Equivalent to AAK47357 from Mycobacterium tuberculosis
                     strain CDC1551 (256 aa) but longer 19 aa. Protein product
                     from Mb2981 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb2981 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A5A0"
                     /db_xref="InterPro:IPR001173"
                     /db_xref="InterPro:IPR029044"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5A0"
BEGIN
        1 MVQTKRYAGL TAANTKKVAM AAPMFSIIIP TLNVAAVLPA CLDSIARQTC GDFELVLVDG
       61 GSTDETLDIA NIFAPNLGER LIIHRDTDQG VYDAMNRGVD LATGTWLLFL GADDSLYEAD
      121 TLARVAAFIG EHEPSDLVYG DVIMRSTNFR WGGAFDLDRL LFKRNICHQA IFYRRGLFGT
      181 IGPYNLRYRV LADWDFNIRC FSNPALVTRY MHVVVASYNE FGGLSNTIVD KEFLKRLPMS
      241 TRLGIRLVIV LVRRWPKVIS RAMVMRTVIS WRRRR
//